J Hum Nutr. 1977 Feb;31(1):11-8.
One hundred and ten adult out-patients entered a prospective study of the effect of dietary control of hyperlipidaemia. Seventy-nine were male and 31 female. Eighty-four patients had primary type II and 26 had primary type IV hyperlipidaemia. Cases of secondary hyperlipidaemia were excluded. Patients with type II hyperlipidaemia were treated with a diet low in saturated fat and cholesterol, with substitution of polyunsaturated fats. Additional carbohydrate and alcohol restriction was applied to patients with type IV hyperlipidaemia. Calorie restriction was prescribed for overweight patients. In type II patients, mean serum cholesterol fell from 322 to 286 mg per 100 ml, and weight from 159 to 152 lb over the first six months of treatment. In type IV patients cholesterol fell from 328 to 281 mg per 100 ml, triglycerides from 389 to 241 mg per 100 ml and weight from 166 to 156 lb over the same period. All reductions were statistically significant at the 1 per cent level. No statistical correlation was observed between reduction of weight and reduction in lipid levels. Over a three-year follow-up period no tendancy for lipid levels or weight to 'rebound' was noted. It is concluded that diet can produce a significant reduction in plasma lipid levels over six months in some hyperlipidaemic patients. Further follow-up is continuing to determine whether this effect can be maintained over the longterm.
110名成年门诊患者参与了一项关于高脂血症饮食控制效果的前瞻性研究。其中男性79名,女性31名。84例患者为原发性II型高脂血症,26例为原发性IV型高脂血症。继发性高脂血症患者被排除在外。II型高脂血症患者采用低饱和脂肪和胆固醇饮食,并以多不饱和脂肪替代。IV型高脂血症患者还需额外限制碳水化合物和酒精摄入。超重患者需限制热量摄入。在II型患者中,治疗的前六个月,平均血清胆固醇从每100毫升322毫克降至286毫克,体重从159磅降至152磅。在IV型患者中,同期胆固醇从每100毫升328毫克降至281毫克,甘油三酯从每100毫升389毫克降至241毫克,体重从166磅降至156磅。所有降低在1%水平上均具有统计学意义。未观察到体重减轻与血脂水平降低之间存在统计学相关性。在三年的随访期内,未发现血脂水平或体重有“反弹”趋势。得出的结论是,饮食可使一些高脂血症患者在六个月内血浆脂质水平显著降低。进一步的随访正在继续,以确定这种效果能否长期维持。