Mertz D P, Wobbe H D, Berger A, Göhmann E
Med Klin. 1977 Jan 14;72(2):47-54.
Six to ten days after conversion from usual alimentary habits to a so-called "reasonable" regimen, the serum concentrations of different lipid fractions were examined under standardized conditions, in a total of 325 in-patients, who had not been pre-treated, and 268 of whom showed - after diverse examinations - a hyperlipoproteinaemia; the other 57 patients had normal lipid values. This diet food is vitamin-rich, poor in calories, protein-rich with a 20 per cent to 25 per cent part of calories, poor in carbohydrates (maximum 120 g/day), and extensively renouncing monomeric and dimeric carbohydrates; furthermore, it contains a percentage of 40 to 45 calories of lipids with a standardized part of multiple-unsaturated fatty acids. During the period of observation, there was in none of the patients an alteration of the body-weight exceeding 1 kg. During the period of the regimen, the following highly significant decreases - without any medicamentous measures - were stated with regard to the serum concentrations: Total cholesterol (average) 9.9 per cent, triglycerides (average) 23.1 per cent, beta-cholesterol (average) 17.6 per cent, and phosphatides (average) 14.2 per cent - all percentages being in relation to the reference values. A hyperproteinaemia (type IIa/Fredrickson) disappeared in 14 out of 18 cases, a hyperlipoproteinaemia (type IIb) in 14 out of 44 cases, and the same happened with this disease type IV in 114 out of 206 cases. A change of type was stated 16 times.
从日常饮食习惯转变为所谓的“合理”饮食方案6至10天后,在标准化条件下对325名未经预处理的住院患者的不同脂质组分的血清浓度进行了检测,其中268名患者经各种检查后显示患有高脂蛋白血症;另外57名患者的血脂值正常。这种减肥食品富含维生素,热量低,富含蛋白质,热量占比20%至25%,碳水化合物含量低(每天最多120克),并大量摒弃单糖和双糖;此外,它含有40%至45%热量的脂质,其中多元不饱和脂肪酸含量标准化。在观察期间,没有一名患者的体重变化超过1千克。在饮食方案实施期间,在未采取任何药物措施的情况下,血清浓度出现了以下高度显著的下降:总胆固醇(平均)下降9.9%,甘油三酯(平均)下降23.1%,β-胆固醇(平均)下降17.6%,磷脂(平均)下降14.2%——所有百分比均相对于参考值。18例中的14例IIa型/弗雷德里克森高蛋白血症消失,44例中的14例IIb型高脂蛋白血症消失,206例中的114例IV型该病也消失。有16次出现类型改变。