Vakoc B, Yun S, de Boer J, Tearney G, Bouma B
Opt Express. 2005 Jul 11;13(14):5483-93. doi: 10.1364/opex.13.005483.
Phase-resolved Doppler optical coherence tomography has been used to image blood flow dynamics in various tissues using both time-domain and spectral-domain optical coherence tomography techniques. In this manuscript, we present phase-resolved Doppler imaging with a high-speed optical frequency domain imaging system. We demonstrate that by correcting for spurious timing-induced phase errors, excellent flow sensitivity can be achieved, limited only by the imaging signal-to-noise ratio. Conventional and Doppler images showing flow in an Intralipid phantom and in human skin are presented. Additionally, we demonstrate the ability of phase-resolved OFDI to measure high flow rates without the deleterious effects of fringe washout.
相分辨多普勒光学相干断层扫描已被用于使用时域和频域光学相干断层扫描技术对各种组织中的血流动力学进行成像。在本论文中,我们展示了利用高速光学频域成像系统进行的相分辨多普勒成像。我们证明,通过校正由杂散定时引起的相位误差,可以实现出色的血流灵敏度,仅受成像信噪比的限制。展示了在脂质乳剂模型和人体皮肤中显示血流的传统图像和多普勒图像。此外,我们证明了相分辨光学频域成像测量高流速的能力,且不会出现条纹模糊的有害影响。