Park B, Pierce Mark C, Cense Barry, Yun Seok-Hyun, Mujat Mircea, Tearney Guillermo, Bouma Brett, de Boer Johannes
Opt Express. 2005 May 30;13(11):3931-44. doi: 10.1364/opex.13.003931.
We demonstrate a high-speed multi-functional spectral-domain optical coherence tomography system, using a broadband light source centered at 1.3 microm and two InGaAs line scan cameras capable of acquiring individual axial scans in 24.4 micros, at a rate of 18,500 axial scans per second. Fundamental limitations on the accuracy of phase determination as functions of signal-to-noise ratio and lateral scan speed are presented and their relative contributions are compared. The consequences of phase accuracy are discussed for both Doppler and polarization-sensitive OCT measurements. A birefringence artifact and a calibration procedure to remove this artifact are explained. Images of a chicken breast tissue sample acquired with the system were compared to those taken with a time-domain OCT system for birefringence measurement verification. The ability of the system to image pulsatile flow in the dermis and to perform functional imaging of large volumes demonstrates the clinical potential of multifunctional spectral-domain OCT.
我们展示了一种高速多功能光谱域光学相干断层扫描系统，该系统使用一个中心波长为1.3微米的宽带光源以及两个能够在24.4微秒内获取单个轴向扫描图像的铟镓砷线扫描相机，每秒可进行18,500次轴向扫描。文中给出了作为信噪比和横向扫描速度函数的相位确定精度的基本限制，并比较了它们的相对贡献。讨论了相位精度对多普勒和偏振敏感型光学相干断层扫描测量的影响。解释了一种双折射伪像以及消除该伪像的校准程序。将用该系统采集的鸡胸组织样本图像与用时域光学相干断层扫描系统采集的图像进行比较，以验证双折射测量结果。该系统对真皮中搏动血流进行成像以及对大体积组织进行功能成像的能力证明了多功能光谱域光学相干断层扫描的临床潜力。
