Weddell G
J Invest Dermatol. 1977 Jul;69(1):130-5. doi: 10.1111/1523-1747.ep12497924.
The histopathology of leprosy is described with particular reference to its effects on peripheral cutaneous nerves. Mycobacterium leprae invade the Schwann and perineurial cells of peripheral cutaneous nerves preferentially. The organisms are eventually destroyed with their host cells by a cell-mediated immune response. The effect is a dying-back phenomenon without the formation of neuromata. The sensory effects are gradually increasing anesthesia and localized nerve trunk pain but seldom any peripheral sensory reference or paresthesiae. Peripheral nerves are shown to be zones where there is some degree of immunologic privilege for Myco. leprae.
麻风病的组织病理学，特别提及了它对外周皮肤神经的影响。麻风分枝杆菌优先侵入外周皮肤神经的施万细胞和神经束膜细胞。这些病原体最终会通过细胞介导的免疫反应与其宿主细胞一起被破坏。其结果是一种“逆行性变性”现象，而不会形成神经瘤。感觉方面的影响是逐渐加重的麻木和局部神经干疼痛，但很少有任何外周感觉异常或感觉异常。外周神经被证明是麻风分枝杆菌具有一定程度免疫豁免的区域。
