Scheutzel P, Gerlach U
Poliklinik und Klinik für Zahnärztliche Prothetik A, Zentrum für Zahn-, Mund- und Kieferheilkunde, Westfälische Wilhelms-Universität Münster, Bundesrepublik Deutschland.
Z Gastroenterol. 1991 Jul;29(7):339-45.
In the serum and saliva of 45 patients with eating disorders and in 30 normal controls, alpha-amylase activity and isoamylase levels were measured. Of the 45 patients evaluated, 12 had restrictive anorexia nervosa, 13 were bulimic anorectics and 20 had bulimia nervosa. In all these groups, the mean alpha-amylase values in serum and saliva were higher than that of the control group. The proportion of pancreatic (P)- and salivary (S)-alpha-amylase isoenzymes in serum were within the normal range for the patient group with restrictive anorexia nervosa, whereas the bulimic anorexia nervosa and bulimia nervosa patients showed significantly greater increases in S- than P-isoamylase activity. The correlation of the salivary alpha-Amylase isoenzym pattern in serum and saliva pointed to the salivary glands as origin of the elevated salivary isoamylase levels in serum. Hyperamylasemia was found in 10 (25%) of the 45 patients with eating disorders. Three of these patients showed besides an increased S-alpha-amylase activity also pathologically elevated P-alpha-amylase and lipase activity in serum; however there were no abdominal symptoms, laboratory data or ultrasonic signs of pancreatitis. In all patients with eating disorders, the mean concentration and secretion of alpha-amylase in saliva were increased. Swelling of the salivary glands was present in 14 patients. In these cases the percentage of salivary-isoamylase activity in total serum alpha-amylase activity was increased significantly, whereas the alpha-amylase secretion in the resting saliva was decreased.
对45例饮食失调患者及30名正常对照者的血清和唾液进行了α淀粉酶活性及同工淀粉酶水平测定。在接受评估的45例患者中，12例为神经性限制型厌食症患者，13例为贪食性厌食症患者，20例为神经性贪食症患者。在所有这些组中，血清和唾液中的平均α淀粉酶值均高于对照组。神经性限制型厌食症患者组血清中胰腺（P）-和唾液（S）-α淀粉酶同工酶的比例在正常范围内，而贪食性厌食症和神经性贪食症患者的S-同工淀粉酶活性比P-同工淀粉酶活性显著增加。血清和唾液中唾液α淀粉酶同工酶模式的相关性表明，唾液腺是血清中唾液同工淀粉酶水平升高的来源。45例饮食失调患者中有10例（25%）出现高淀粉酶血症。其中3例患者除S-α淀粉酶活性增加外，血清中P-α淀粉酶和脂肪酶活性也呈病理性升高；然而，没有胰腺炎的腹部症状、实验室数据或超声迹象。在所有饮食失调患者中，唾液中α淀粉酶的平均浓度和分泌量均增加。14例患者出现唾液腺肿大。在这些病例中，血清总α淀粉酶活性中唾液同工淀粉酶活性的百分比显著增加，而静息唾液中的α淀粉酶分泌减少。
