Sakou Irine-Ikbale, Tzanakaki Georgina, Tsolia Maria N, Sioumala Maria, Barbouni Anastasia, Kyprianou Miltiades, Papaevangelou Vana, Tsitsika Artemis, Blackwell Caroline C, Kafetzis Dimitris, Kremastinou Jenny
National Meningitis Reference Laboratory, National School of Public Health, 196, Alexandras Avenue, Athens, Greece.
Vaccine. 2009 Jul 16;27(33):4408-11. doi: 10.1016/j.vaccine.2009.05.047. Epub 2009 Jun 3.
Serogroup C meningococcal conjugate vaccines were introduced in Greece in 2001, and although no cases of serogroup C meningococcal disease were recorded in 2004, a steady increase was observed since 2005. In this study, serum bactericidal activity was assessed in sera of 269 vaccinated children at a mean time of about 5 years after vaccination. Non-protective antibody titers were observed in most children vaccinated at age <6 years (85.9%), followed by those between 6 and 10 years (62.2%). This percentage was considerably lower in adolescents vaccinated at an age >10 years (37.8%) (p<0.01). Geometric mean concentrations of serum IgG antibodies against serogroup C showed a similar variation. The results indicate that serum bactericidal antibody titers significantly correlate with age of vaccination; most children do not have protective antibody titers few years after immunization in infancy and childhood whereas most adolescents maintain sustained protection.
2001年希腊引进了C群脑膜炎球菌结合疫苗，尽管2004年未记录到C群脑膜炎球菌病病例，但自2005年以来病例数呈稳步上升趋势。在本研究中，对269名接种疫苗儿童在接种后平均约5年时的血清进行了杀菌活性评估。大多数6岁以下接种疫苗的儿童（85.9%）观察到非保护性抗体滴度，其次是6至10岁的儿童（62.2%）。10岁以上接种疫苗的青少年中这一比例显著较低（37.8%）（p<0.01）。针对C群血清IgG抗体的几何平均浓度显示出类似变化。结果表明，血清杀菌抗体滴度与接种年龄显著相关；大多数儿童在婴儿期和儿童期免疫后几年没有保护性抗体滴度，而大多数青少年保持持续保护。
