与系统性红斑狼疮相关的神经精神症状中涉及的自身抗体。

Autoantibodies involved in neuropsychiatric manifestations associated with systemic lupus erythematosus.

作者信息

Colasanti Tania, Delunardo Federica, Margutti Paola, Vacirca Davide, Piro Ettore, Siracusano Alessandra, Ortona Elena

机构信息

Department of Infectious, Parasitic and Immune-Mediated Diseases Istituto Superiore di Sanità, Rome, Italy.

出版信息

J Neuroimmunol. 2009 Jul 25;212(1-2):3-9. doi: 10.1016/j.jneuroim.2009.05.003. Epub 2009 Jun 4.

DOI:10.1016/j.jneuroim.2009.05.003

PMID:19500858

Abstract

In the course of Systemic Lupus Erythematosus (SLE), a variety of neuropsychiatric disturbances is reported with a prevalence ranging from 17% to 75%. The diagnosis of these syndromes is difficult and requires a careful psychiatric evaluation. Distinct autoantibodies detectable in serum or cerebrospinal fluid of patients with SLE are associated with the presence of neuropsychiatric disorders. These autoantibodies may have a pathogenic relevance in neuropsychiatric SLE or they may be merely an epiphenomenon. This review describes the various autoantibodies reported to be associated with neuropsychiatric manifestations in SLE and discusses their possible role.

摘要

在系统性红斑狼疮（SLE）病程中，据报道会出现多种神经精神障碍，患病率在17%至75%之间。这些综合征的诊断困难，需要进行仔细的精神科评估。在SLE患者血清或脑脊液中可检测到的特定自身抗体与神经精神障碍的存在相关。这些自身抗体可能在神经精神性SLE中具有致病相关性，也可能仅仅是一种附带现象。本综述描述了据报道与SLE神经精神表现相关的各种自身抗体，并讨论了它们可能的作用。