Pereira R M, Yoshinari N H, De Oliveira R M, Cossermelli W
Department of Rheumatology, University of Sao Paulo, School of Medicine, Brasil.
Lupus. 1992 May;1(3):175-9. doi: 10.1177/096120339200100309.
Antiganglioside antibodies (AGA) were determined in sera and cerebrospinal fluids (CSF) from 50 systemic lupus erythematosus (SLE) patients, and age-matched normal controls. The SLE patients were subdivided according to the type of clinical manifestation into two groups: neuropsychiatric SLE and active SLE without neuropsychiatric manifestation. The presence of these antibodies showed a significant correlation between IgG AGA in the CSF and IgM AGA in the serum and neuropsychiatric SLE. Fifteen patients had this antibody in the CSF without detectable levels in the serum. No correlation was seen between anticardiolipin antibodies in the serum of CSF and neuropsychiatric SLE. The present work suggests that antibodies against gangliosides may be a marker for neuropsychiatric SLE and that intrathecal antibody production can result in the development of this manifestation.
在50例系统性红斑狼疮（SLE）患者以及年龄匹配的正常对照者的血清和脑脊液（CSF）中检测了抗神经节苷脂抗体（AGA）。根据临床表现类型，将SLE患者分为两组：神经精神性SLE和无神经精神表现的活动性SLE。这些抗体的存在表明脑脊液中的IgG AGA与血清中的IgM AGA和神经精神性SLE之间存在显著相关性。15例患者脑脊液中有这种抗体，而血清中检测不到。脑脊液或血清中的抗心磷脂抗体与神经精神性SLE之间未发现相关性。目前的研究表明，抗神经节苷脂抗体可能是神经精神性SLE的一个标志物，鞘内抗体产生可导致这种表现的发生。
