Sippl Manfred J
Division of Bioinformatics, University of Salzburg, Hellbrunnerstrasse 34, A-5020 Salzburg, Austria.
Curr Opin Struct Biol. 2009 Jun;19(3):312-20. doi: 10.1016/j.sbi.2009.03.010. Epub 2009 Jun 6.
You want to know how proteins do it? Take a walk in protein fold space. More often than not you will get a clue if not the answer. If you know what you are looking for and how to find it. In fact, there is more information than we can presently handle. Charting fold space and chasing its creatures has occupied us for the past decades. There is no end in sight.
你想知道蛋白质是如何做到的吗？在蛋白质折叠空间中漫步。通常情况下，即便得不到答案，你也会找到一些线索，只要你知道自己在寻找什么以及如何去寻找。事实上，这里的信息多得超出了我们目前的处理能力。在过去几十年里，绘制折叠空间并追踪其中的“生物”一直让我们忙碌不已，而且看不到尽头。
