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丙型肝炎病毒NS5B聚合酶抑制剂：N-烷基-4-羟基喹诺酮-3-基-苯并噻二嗪磺酰胺的合成及构效关系

Inhibitors of HCV NS5B polymerase: synthesis and structure-activity relationships of N-alkyl-4-hydroxyquinolon-3-yl-benzothiadiazine sulfamides.

作者信息

Krueger A Chris, Madigan Darold L, Jiang Wen W, Kati Warren M, Liu Dachun, Liu Yaya, Maring Clarence J, Masse Sherie, McDaniel Keith F, Middleton Tim, Mo Hongmei, Molla Akhteruzzaman, Montgomery Debra, Pratt John K, Rockway Todd W, Zhang Rong, Kempf Dale J

机构信息

Infectious Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA.

出版信息

Bioorg Med Chem Lett. 2006 Jul 1;16(13):3367-70. doi: 10.1016/j.bmcl.2006.04.015. Epub 2006 May 2.

DOI:10.1016/j.bmcl.2006.04.015
PMID:16650764
Abstract

Substituted N-alkyl-4-hydroxyquinolon-3-yl-benzothiadiazine sulfamides were investigated as inhibitors of genotype 1 HCV polymerase. Structure-activity relationship patterns for this class of compounds are discussed.

摘要

对取代的N-烷基-4-羟基喹诺酮-3-基-苯并噻二嗪磺酰胺作为1型丙型肝炎病毒聚合酶抑制剂进行了研究。讨论了这类化合物的构效关系模式。

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