Vita-Salute San Raffaele University, Division of Neuroscience-IRCCS San Raffaele, National Institute of Neuroscience and IBFM-CNR, Milan, Italy.
Neurobiol Aging. 2011 May;32(5):875-84. doi: 10.1016/j.neurobiolaging.2009.05.004. Epub 2009 Jun 5.
Though neuroimaging, pathology and pathophysiology suggest a subcortical and deep cortical involvement in Frontotemporal Lobar Degeneration (FTLD), no studies have comprehensively assessed the associated gray matter (GM) volume changes. We measured caudate, putamen, thalamus, and amygdala GM volume using probabilistic a-priori regions of interest (ROIs) in 53 early FTLD patients (38 behavioral variant FTD [bvFTD], 9 Semantic Dementia [SD], 6 Progressive Non-Fluent Aphasia [PNFA]), and 25 age-matched healthy controls (HC). ANOVA showed significant (P<0.001) main effect of diagnosis, and significant interactions for diagnosis and region, and diagnosis and hemisphere. Post-hoc comparisons with HC showed bilateral GM atrophy in the caudate, putamen and thalamus, in bvFTD; a left-confined GM reduction in the amygdala in SD; and bilateral GM atrophy in the caudate and thalamus, and left-sided GM reduction in the putamen and amygdala in PNFA. Correlation analyses suggested an association between GM volumes and language, psychomotor speed and behavioral disturbances. This study showed a widespread involvement of subcortical and deep cortical GM in early FTLD with patterns specific for clinical entity.
尽管神经影像学、病理学和病理生理学提示额颞叶变性（FTLD）涉及皮质下和深部皮质，但尚无研究全面评估相关的灰质（GM）体积变化。我们使用概率先验 ROI 在 53 名早期 FTLD 患者（38 名行为变异型额颞叶痴呆[bvFTD]、9 名语义性痴呆[SD]、6 名进行性非流利性失语症[PNFA]）和 25 名年龄匹配的健康对照组（HC）中测量了尾状核、壳核、丘脑和杏仁核的 GM 体积。方差分析显示诊断有显著（P<0.001）的主效应，以及诊断与区域、诊断与半球之间的显著交互作用。与 HC 的事后比较显示，在 bvFTD 中双侧尾状核、壳核和丘脑 GM 萎缩；在 SD 中左侧杏仁核 GM 减少局限于左侧；在 PNFA 中双侧尾状核和丘脑 GM 萎缩，以及双侧壳核和杏仁核 GM 减少局限于左侧。相关性分析表明 GM 体积与语言、运动速度和行为障碍之间存在关联。这项研究显示，在早期 FTLD 中，皮质下和深部皮质 GM 广泛受累，且具有特定的临床实体模式。
