Yang Jian-Kang, Gong Yuan-Ying, Xie Liang, Lian Shi-Gang, Yang Juan, Xu Liang-You, Gao Shou-Jun, Zhang Ya-Ping
Laboratory for Conservation and Utilisation of Bio-resource, Yunnan University, Kunming, China.
J Renin Angiotensin Aldosterone Syst. 2009 Jun;10(2):115-8. doi: 10.1177/1470320309104873.
The insertion/deletion polymorphism of the angiotensin-converting enzyme (ACE) gene has been reported to associate with human longevity. However, little information is available in a Han Chinese longevity population.Therefore, we investigated the association of the ACE gene insertion/ deletion polymorphism with longevity in a Han Chinese population.
We compared the distribution of ACE insertion/deletion genotype and allele frequencies in two groups: a longevity group (399 subjects) aged over 90 years and a control group (302 subjects) aged less than 60 years.
No difference in genotype and allele frequencies of the ACE gene insertion/deletion polymorphism was observed between the longevity group and the control group.When adjusting for gender, the difference between the longevity group and the control group was also not significant regarding the frequencies of the genotypes (male, p=0.994 and female, p=0.797) as well as allele frequencies (male, p=0.969 and female, p=0.884).
No association of the ACE gene insertion/deletion polymorphism with longevity was observed in our Han Chinese population.
据报道，血管紧张素转换酶（ACE）基因的插入/缺失多态性与人类长寿有关。然而，关于汉族长寿人群的相关信息却很少。因此，我们调查了ACE基因插入/缺失多态性与汉族人群长寿之间的关联。
我们比较了两组人群中ACE插入/缺失基因型和等位基因频率的分布：一组是90岁以上的长寿组（399名受试者），另一组是60岁以下的对照组（302名受试者）。
长寿组与对照组之间，未观察到ACE基因插入/缺失多态性的基因型和等位基因频率存在差异。在对性别进行校正后，长寿组与对照组在基因型频率（男性，p = 0.994；女性，p = 0.797）以及等位基因频率（男性，p = 0.969；女性，p = 0.884）方面的差异也不显著。
在我们的汉族人群中，未观察到ACE基因插入/缺失多态性与长寿之间存在关联。
