Kamiya M, Tateyama H, Fujiyoshi Y, Tada T, Eimoto T, Shibata H, Hashizume Y
Department of Pathology, Nagoya City University Medical School, Japan.
Acta Cytol. 1991 Nov-Dec;35(6):757-60.
The present case shows the usefulness of cerebrospinal fluid (CSF) cytology in the diagnosis of leptomeningeal dissemination by immature teratoma. The tumor arose in the thoracolumbar spinal cord of a 14-year-old male. The initial histopathologic diagnosis was made on the tumor tissue taken at laminectomy. Postoperatively, CSF cytology revealed epithelial cell clusters, scattered squamous epithelial cells and small bundles of striated muscle fibers in the background of many histiocytes and inflammatory cells. Although these cells showed only slight cytologic atypia, their presence in the subarachnoid space suggested the leptomeningeal spread of well-differentiated portions of the immature teratoma. The postmortem examination revealed the primary tumor in the spinal cord and multiple metastatic nodules in the brain.
本病例显示了脑脊液（CSF）细胞学检查在未成熟畸胎瘤软脑膜播散诊断中的作用。肿瘤发生于一名14岁男性的胸腰段脊髓。最初的组织病理学诊断是基于椎板切除术中获取的肿瘤组织做出的。术后，脑脊液细胞学检查显示上皮细胞簇、散在的鳞状上皮细胞以及在许多组织细胞和炎性细胞背景中的小束横纹肌纤维。尽管这些细胞仅表现出轻微的细胞学异型性，但它们在蛛网膜下腔的存在提示未成熟畸胎瘤分化良好部分的软脑膜播散。尸检发现脊髓原发性肿瘤和脑内多个转移结节。
