Ali S Z, Semmelmeier S B, Urmacher C
Department of Laboratories, North Shore University Hospital-Cornell University Medical College, Manhasset, New York 11030, USA.
Acta Cytol. 1995 Jul-Aug;39(4):766-9.
The cytologic findings on cerebrospinal fluid examination of cervical chordoma in a 2-year-old girl are presented. The major cell type was a small, isolated, hyperchromatic cell with sharply defined nuclear membrane and granular cytoplasm. However, the characteristic cell of this neoplasm, the so-called physaliferous cell with typical bubbly cytoplasm, was also noted. Cytologic findings were compared to biopsy findings, with a good correlation of tumor morphology. Clinical follow-up revealed unusually aggressive tumor behavior, and the patient died a year later despite intensive chemotherapy. The differential diagnosis of the condition is also discussed.
本文报告了一名2岁女童颈椎脊索瘤的脑脊液检查细胞学结果。主要细胞类型为小的、孤立的、核深染的细胞，核膜清晰，细胞质呈颗粒状。然而，也发现了该肿瘤的特征性细胞，即具有典型泡沫状细胞质的所谓大空泡细胞。将细胞学结果与活检结果进行了比较，肿瘤形态具有良好的相关性。临床随访显示肿瘤行为异常侵袭性，尽管进行了强化化疗，患者一年后仍死亡。本文还讨论了该疾病的鉴别诊断。
