Nance K V, Park H K, Silverman J F
Department of Pathology and Laboratory Medicine, East Carolina University School of Medicine, Greenville, North Carolina 27858-4354.
Acta Cytol. 1991 Nov-Dec;35(6):765-9.
The cytologic features of a recurrent desmoplastic malignant melanoma (DMM) examined by fine needle aspiration biopsy are reported. Cytologic examination revealed multiple microtissue fragments as well as smaller, dissociative aggregates composed predominantly of spindle-shaped neoplastic cells with hyperchromatic nuclei, small but prominent nucleoli and no cytoplasmic pigment or intranuclear pseudoinclusions. The tumor cells exhibited weak cytoplasmic staining for S-100 protein. To the best of our knowledge, this is the first reported case report describing the cytologic findings of DMM. Problems in differential diagnosis are discussed.
报告了通过细针穿刺活检检查复发性促纤维增生性恶性黑色素瘤（DMM）的细胞学特征。细胞学检查显示有多个微小组织碎片以及较小的、离散的细胞聚集体，主要由梭形肿瘤细胞组成，这些细胞具有核深染、小而突出的核仁，无细胞质色素或核内假包涵体。肿瘤细胞对S-100蛋白呈弱阳性细胞质染色。据我们所知，这是第一例报道描述促纤维增生性恶性黑色素瘤细胞学表现的病例报告。文中讨论了鉴别诊断中的问题。
