Tsuda H, Ishii T, Sawada T, Takatsuki K
Second Department of Internal Medicine, Kumamoto University School of Medicine, Japan.
Acta Haematol. 1991;86(1):31-5. doi: 10.1159/000204795.
Thirty-seven patients with adult T-cell leukemia had serum beta 2-microglobulin (beta 2M) estimated at presentation. A significant association was found between beta 2M and the subtypes of the disease: beta 2M in the acute type is significantly higher than in the chronic and smoldering types (p less than 0.01), and beta 2M in the lymphoma type is apparently higher than in the chronic and smoldering types, although the difference between the lymphoma and chronic types was not statistically significant. An apparent reduction in beta 2M levels after chemotherapy was observed in 7 patients who reached partial or complete remission. One patient who was resistant to chemotherapy showed elevated beta 2M values even after intensive chemotherapy. In another patient, who attained partial remission with a concordant reduction in beta 2M, renewed elevation of beta 2M was observed in parallel with exacerbation of other parameters such as lactate dehydrogenase (LDH), WBC, calcium and clinical manifestations. Correlation analysis was carried out between beta 2M, LDH, calcium, lymphoid cell count and the grade of clinical severity. The beta 2M level was moderately correlated with LDH, calcium, the grade of clinical severity but not with the lymphoid cell count. The clinical severity also correlated with LDH and calcium but to a lesser extent than with beta 2M. These data support the use of the beta 2M in the evaluation of adult T-cell leukemia.
37例成人T细胞白血病患者在初诊时测定了血清β2-微球蛋白（β2M）。发现β2M与该疾病的亚型之间存在显著关联：急性型患者的β2M显著高于慢性型和隐匿型（p<0.01），淋巴瘤型患者的β2M明显高于慢性型和隐匿型，尽管淋巴瘤型与慢性型之间的差异无统计学意义。7例达到部分或完全缓解的患者在化疗后观察到β2M水平明显降低。1例对化疗耐药的患者即使在强化化疗后β2M值仍升高。另1例患者达到部分缓解且β2M相应降低，随着乳酸脱氢酶（LDH）、白细胞、钙及临床表现等其他参数的恶化，观察到β2M再次升高。对β2M、LDH、钙、淋巴细胞计数及临床严重程度分级进行了相关性分析。β2M水平与LDH、钙及临床严重程度分级呈中度相关，但与淋巴细胞计数无关。临床严重程度也与LDH和钙相关，但程度低于与β2M的相关性。这些数据支持将β2M用于成人T细胞白血病的评估。
