Itoh Y, Ohtaki H, Ono T, Mori N, Kawaoi A, Kawai T
Department of Clinical Pathology, Jichi Medical School, Japan.
Acta Haematol. 1991;86(2):107-10. doi: 10.1159/000204814.
A 69-year-old man with a rare case of lymphoma-type alpha-chain disease was admitted to the hospital with marked cervical and inguinal lymph node swelling. Lymph node biopsy showed marked infiltration of plasma cells, plasmacytoid cells and immunoblastoid cells, alone or in combination. Immunoelectrophoresis and immunoselection identified alpha-chain in the serum and urine. The site of alpha-chain synthesis was extensively studied in the whole body, and the immunoperoxidase technique eventually demonstrated the presence of alpha-chains in the cytoplasm of infiltrating malignant cells in the lymph nodes. No infiltrating malignant cells were found in other organs or tissues, including those of the digestive and respiratory tracts.
一名69岁男性，患罕见的淋巴瘤型α链病，因颈部和腹股沟淋巴结明显肿大入院。淋巴结活检显示浆细胞、浆细胞样细胞和免疫母细胞单独或联合显著浸润。免疫电泳和免疫筛选在血清和尿液中鉴定出α链。对α链合成部位进行了全身广泛研究，免疫过氧化物酶技术最终证实淋巴结中浸润性恶性细胞的细胞质中存在α链。在包括消化道和呼吸道在内的其他器官或组织中未发现浸润性恶性细胞。
