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3型兰尼碱受体（RyR3）基因敲除小鼠的综合行为表型分析：在两项社交互动测试中社交接触持续时间减少

Comprehensive behavioral phenotyping of ryanodine receptor type 3 (RyR3) knockout mice: decreased social contact duration in two social interaction tests.

作者信息

Matsuo Naoki, Tanda Koichi, Nakanishi Kazuo, Yamasaki Nobuyuki, Toyama Keiko, Takao Keizo, Takeshima Hiroshi, Miyakawa Tsuyoshi

机构信息

Division of Systems Medical Science, Institute for Comprehensive Medical Science, Fujita Health University Toyoake, Japan.

出版信息

Front Behav Neurosci. 2009 May 7;3:3. doi: 10.3389/neuro.08.003.2009. eCollection 2009.

DOI:10.3389/neuro.08.003.2009
PMID:19503748
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2691151/
Abstract

Dynamic regulation of the intracellular Ca2+ concentration is crucial for various neuronal functions such as synaptic transmission and plasticity, and gene expression. Ryanodine receptors (RyRs) are a family of intracellular calcium release channels that mediate calcium-induced calcium release from the endoplasmic reticulum. Among the three RyR isoforms, RyR3 is preferentially expressed in the brain especially in the hippocampus and striatum. To investigate the behavioral effects of RyR3 deficiency, we subjected RyR3 knockout (RyR3-/-) mice to a battery of behavioral tests. RyR3-/- mice exhibited significantly decreased social contact duration in two different social interaction tests, where two mice can freely move and make contacts with each other. They also exhibited hyperactivity and mildly impaired prepulse inhibition and latent inhibition while they did not show significant abnormalities in motor function and working and reference memory tests. These results indicate that RyR3 has an important role in locomotor activity and social behavior.

摘要

细胞内钙离子浓度的动态调节对于各种神经元功能（如突触传递、可塑性和基因表达）至关重要。兰尼碱受体（RyRs）是一类细胞内钙释放通道，介导内质网的钙诱导钙释放。在三种RyR亚型中，RyR3在大脑中优先表达，尤其是在海马体和纹状体中。为了研究RyR3缺乏的行为影响，我们对RyR3基因敲除（RyR3-/-）小鼠进行了一系列行为测试。在两种不同的社交互动测试中，RyR3-/-小鼠的社交接触时间显著减少，在这两种测试中，两只小鼠可以自由移动并相互接触。它们还表现出多动、前脉冲抑制和潜伏抑制轻度受损，而在运动功能、工作和参考记忆测试中未表现出明显异常。这些结果表明，RyR3在运动活动和社交行为中具有重要作用。

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