度洛西汀治疗压力性尿失禁的研究进展。
Update on duloxetine for the management of stress urinary incontinence.
机构信息
Department of Obstetrics and Gynaecology, Medway Maritime Hospital, Gillingham, Kent, UK.
出版信息
Clin Interv Aging. 2009;4:25-30. Epub 2009 May 14.
Abstract
Duloxetine is a relatively balanced serotonin and noradrenaline reuptake inhibitor (SNRI), which is the first drug with widely proven efficacy to have been licensed for the medical treatment of women with stress urinary incontinence (SUI). Despite favorable results from randomized controlled trials, surgical management continues to be the mainstay of treatment for SUI. In this review we explore the pharmacology of duloxetine in the nervous system and lower urinary tract, and the evidence for its use in the management of women with urinary incontinence.
摘要
度洛西汀是一种相对平衡的 5-羟色胺和去甲肾上腺素再摄取抑制剂（SNRI），它是第一种经广泛验证有效而被批准用于治疗女性压力性尿失禁（SUI）的药物。尽管随机对照试验结果良好，但手术治疗仍然是 SUI 的主要治疗方法。在这篇综述中，我们探讨了度洛西汀在神经系统和下尿路中的药理学作用，以及它在治疗尿失禁女性中的应用证据。
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