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Hyperglycaemia and hyperinsulinaemia: is insulin-degrading enzyme the missing link?

作者信息

Fawcett J, Duckworth W C

机构信息

Research Service, Phoenix VA Health Care System, Phoenix, AZ 85012, USA.

出版信息

Diabetologia. 2009 Aug;52(8):1457-60. doi: 10.1007/s00125-009-1414-8. Epub 2009 Jun 6.

DOI:10.1007/s00125-009-1414-8
PMID:19504084
Abstract
摘要

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Glucose inhibits the insulin-induced activation of the insulin-degrading enzyme in HepG2 cells.葡萄糖抑制胰岛素诱导的HepG2细胞中胰岛素降解酶的激活。
Diabetologia. 2009 Aug;52(8):1656-64. doi: 10.1007/s00125-009-1350-7. Epub 2009 Apr 25.
2
How the binding and degrading capabilities of insulin degrading enzyme are affected by ubiquitin.胰岛素降解酶的结合和降解能力是如何受到泛素影响的。
Biochim Biophys Acta. 2008 Jul-Aug;1784(7-8):1122-6. doi: 10.1016/j.bbapap.2008.04.011. Epub 2008 May 1.
3
Regulation of protein degradation by insulin-degrading enzyme: analysis by small interfering RNA-mediated gene silencing.
Insulin-degrading enzyme binds to the nonglycosylated precursor of varicella-zoster virus gE protein found in the endoplasmic reticulum.
胰岛素降解酶与内质网中发现的水痘带状疱疹病毒 gE 蛋白的非糖基化前体结合。
J Virol. 2010 Jan;84(2):847-55. doi: 10.1128/JVI.01801-09. Epub 2009 Oct 28.
胰岛素降解酶对蛋白质降解的调控：通过小干扰RNA介导的基因沉默进行分析
Arch Biochem Biophys. 2007 Dec 1;468(1):128-33. doi: 10.1016/j.abb.2007.09.019. Epub 2007 Sep 29.
4
Positive association between risk for late-onset Alzheimer disease and genetic variation in IDE.迟发性阿尔茨海默病风险与胰岛素降解酶（IDE）基因变异之间的正相关关系。
Neurobiol Aging. 2007 Sep;28(9):1374-80. doi: 10.1016/j.neurobiolaging.2006.06.017. Epub 2006 Jul 31.
5
Alternative splicing of human insulin-degrading enzyme yields a novel isoform with a decreased ability to degrade insulin and amyloid beta-protein.人胰岛素降解酶的可变剪接产生一种新的异构体，其降解胰岛素和β-淀粉样蛋白的能力降低。
Biochemistry. 2005 May 3;44(17):6513-25. doi: 10.1021/bi0476578.
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Alternative translation initiation generates a novel isoform of insulin-degrading enzyme targeted to mitochondria.选择性翻译起始产生一种靶向线粒体的胰岛素降解酶新亚型。
Biochem J. 2004 Nov 1;383(Pt. 3):439-46. doi: 10.1042/BJ20041081.
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Reduced action of insulin glargine on protein and lipid metabolism: possible relationship to cellular hormone metabolism.甘精胰岛素对蛋白质和脂质代谢的作用减弱：与细胞激素代谢的可能关系。
Metabolism. 2004 Aug;53(8):1037-44. doi: 10.1016/j.metabol.2004.02.013.
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Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein.导致糖尿病的胰岛素降解酶部分功能丧失突变也会损害β-淀粉样蛋白的降解。
Am J Pathol. 2004 Apr;164(4):1425-34. doi: 10.1016/s0002-9440(10)63229-4.
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Genetic variation in a haplotype block spanning IDE influences Alzheimer disease.跨越胰岛素降解酶（IDE）的单倍型块中的基因变异会影响阿尔茨海默病。
Hum Mutat. 2003 Nov;22(5):363-71. doi: 10.1002/humu.10282.
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Insulin inhibition of the proteasome is dependent on degradation of insulin by insulin-degrading enzyme.胰岛素对蛋白酶体的抑制作用取决于胰岛素被胰岛素降解酶的降解。
J Endocrinol. 2003 Jun;177(3):399-405. doi: 10.1677/joe.0.1770399.