2型糖尿病中与胰岛相关的巨噬细胞 - Suppr

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Islet-associated macrophages in type 2 diabetes.

作者信息

Richardson S J, Willcox A, Bone A J, Foulis A K, Morgan N G

出版信息

Diabetologia. 2009 Aug;52(8):1686-8. doi: 10.1007/s00125-009-1410-z. Epub 2009 Jun 6.

DOI:10.1007/s00125-009-1410-z

PMID:19504085

Abstract

摘要

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Islet-associated macrophages in type 2 diabetes.2型糖尿病中与胰岛相关的巨噬细胞

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Distinctions between islet neogenesis and β-cell replication: implications for reversal of Type 1 and 2 diabetes.胰岛新生与β细胞复制的区别：对 1 型和 2 型糖尿病逆转的影响。

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Opposing effects of IL-1β/COX-2/PGE2 pathway loop on islets in type 2 diabetes mellitus.IL-1β/COX-2/PGE2 通路环对 2 型糖尿病胰岛的相反作用。

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Islet macrophages are associated with islet vascular remodeling and compensatory hyperinsulinemia during diabetes.胰岛巨噬细胞与糖尿病期间胰岛血管重塑和代偿性高胰岛素血症有关。

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Loss of beta-cells with fibrotic islet destruction in type 2 diabetes mellitus.2型糖尿病中β细胞丧失伴胰岛纤维化破坏。

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Loss of β-arrestin2 mediates pancreatic-islet dysfunction in mice.β-arrestin2 缺失导致小鼠胰岛功能障碍。

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LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus.LRH-1 激动剂有利于免疫胰岛对话，从而预防糖尿病。

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Macrophages and islet inflammation in type 2 diabetes.巨噬细胞与 2 型糖尿病胰岛炎症

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The resident macrophages in murine pancreatic islets are constantly probing their local environment, capturing beta cell granules and blood particles.胰岛内的固有巨噬细胞不断探测其局部微环境，捕获β细胞颗粒和血液颗粒。

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Resident macrophages mediate islet amyloid polypeptide-induced islet IL-1β production and β-cell dysfunction.驻留巨噬细胞介导胰岛淀粉样多肽诱导的胰岛白细胞介素-1β产生和β细胞功能障碍。

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Resident memory CD8(+) T cells dominate lymphoid immune cell population in human pancreatic islets in health and type 2 diabetes.驻留记忆性CD8(+) T细胞在健康人和2型糖尿病患者的人胰岛淋巴样免疫细胞群体中占主导地位。

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Islet-resident macrophage-derived miR-155 promotes β cell decompensation via targeting PDX1.胰岛驻留巨噬细胞衍生的miR-155通过靶向PDX1促进β细胞功能不全。

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CSF1R inhibition with PLX5622 affects multiple immune cell compartments and induces tissue-specific metabolic effects in lean mice.CSF1R 抑制作用会影响多种免疫细胞群，并在瘦小鼠中诱导组织特异性代谢效应。

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本文引用的文献

The prevalence of enteroviral capsid protein vp1 immunostaining in pancreatic islets in human type 1 diabetes.人1型糖尿病患者胰岛中肠道病毒衣壳蛋白vp1免疫染色的患病率

Diabetologia. 2009 Jun;52(6):1143-51. doi: 10.1007/s00125-009-1276-0. Epub 2009 Mar 6.

Analysis of islet inflammation in human type 1 diabetes.人类1型糖尿病中胰岛炎症的分析。

Clin Exp Immunol. 2009 Feb;155(2):173-81. doi: 10.1111/j.1365-2249.2008.03860.x.

Increased number of islet-associated macrophages in type 2 diabetes.2型糖尿病中胰岛相关巨噬细胞数量增加。

Diabetes. 2007 Sep;56(9):2356-70. doi: 10.2337/db06-1650. Epub 2007 Jun 19.

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