Pujol J, Junqué C, Vendrell P, Capdevila A, Martí-Vilalta J L
Department of Psychiatry, University of Barcelona, Spain.
Acta Neurol Scand. 1991 Sep;84(3):237-42.
We studied the cognitive significance of ventricular enlargement in 40 vascular patients with leuko-araiosis on MRI. We obtained significant differences between patients and normal controls without vascular risk-factors regarding ventricular measures. Ventricular size of the patients correlated with several neuropsychological tests measuring abstract reasoning, comprehension of language, constructional skills, speed and attention. These results suggest that ventricular enlargement in vascular patients reflects global deterioration of complex cognitive functions. Information proceeding from ventricular size is complementary to that coming from the degree of leuko-araiosis and probably has more clinical significance. Both leuko-araiosis and ventricular size may be neuroimaging parameters capable of reflecting the cognitive deterioration in vascular patients without large lesions.
我们研究了40例MRI显示有脑白质疏松的血管性疾病患者脑室扩大的认知意义。在脑室测量方面，我们发现有血管危险因素的患者与无血管危险因素的正常对照之间存在显著差异。患者的脑室大小与多项测量抽象推理、语言理解、构建技能、速度和注意力的神经心理学测试相关。这些结果表明，血管性疾病患者的脑室扩大反映了复杂认知功能的整体衰退。来自脑室大小的信息与来自脑白质疏松程度的信息互为补充，且可能具有更大的临床意义。脑白质疏松和脑室大小可能都是能够反映无大面积病变的血管性疾病患者认知衰退的神经影像学参数。
