Tomilin N V
Tsitologiia. 2009;51(4):291-6.
Published data are reviewed on the mechanism of inheritance of repressive epigenetic modifications of chromatin, histone and DNA, which suggest that they depend on RNA. RNA is transcribed from most of genome compartments and when it forms duplex structures because of overlapping transcription or because of resynthesis by RNA-dependent RNA polymerase, heterochromatin is generated. Mitotic phosphorylation of Ser-10 in histone H3 stimulates transcription of heterochromatin and its recovery in the next cell cycle by RNA interference.
已发表的数据回顾了染色质、组蛋白和DNA的抑制性表观遗传修饰的遗传机制，这些机制表明它们依赖于RNA。RNA从基因组的大部分区域转录而来，当由于转录重叠或依赖RNA的RNA聚合酶重新合成而形成双链结构时，异染色质就会产生。组蛋白H3中Ser-10的有丝分裂磷酸化通过RNA干扰刺激异染色质的转录及其在下一个细胞周期中的恢复。
