Influence of the redox-state potential of biophase on electrically stimulated skeletal muscles (myographic and voltage-clamp analysis).

Redox modulation of cholinergic and adrenergic mechanisms of excitatory tissues have been analyzed rather satisfactorily until recently. The aim of the present work is to give some initial guiding information about the redox modulation of electrogenic excitatory processes in skeletal muscles. It was observed, that on increasing the tissue redox-state potential (E0'), the amplitudes of muscle contractions are higher by 18.5 per cent than controls, but decreasing E0', the amplitudes of muscle contractions are lower by 10.5 per cents than controls. It means, that muscle contractions elicited by electric stimulation are also under redox control. One of the mechanisms responsible for this phenomenon is that following increased E0' values both peak current (Ip) and steady-state current (ISS) increases, but after decreased E0' values ISS decreases. The role of other site of actions and mechanisms, i.e. ion channels, active transport, excitation-contraction coupling, and Na(+)-Ca2+ exchange diffusion processes, are also discussed.