Puppi A, Dely M
Central Laboratory of Animal Research, University Medical School, Hungary.
Acta Physiol Hung. 1991;77(1):43-56.
In CFY rats the tissue redox-state potential (E0') in heart, m. vastus medialis and in the liver, and the heart frequency and QRS amplitudes were measured parallel. It was observed that following compensatory redosis caused by konakion both the autorhythmic heart frequency and QRS amplitudes increased, while after compensatory oxidosis induced by urea occurred the opposite. Following compensatory redosis caused by konakion acetylcholine decreased, but adrenaline increased the heart frequency and QRS amplitudes more intensively than at normal E0' values. After compensatory oxidosis caused by urea, acetylcholine decreased the heart frequency and QRS amplitudes significantly less. Adrenaline decreased the heart frequency in such milieu. On the basis of these data the following conclusions are proposed; For the realization of autorhythmic activity, for negative type acetylcholine and for positive type adrenaline effects in heart, a relatively low primordial tissue E0' value is an essential back-ground element. Among the mechanisms controlling autorhythmicity and sympathetic/parasympathetic effects the actual and permanently changing tissue E0' value is also an important modifying, or through biochemical redox feed-back mechanisms even a regulatory factor of heart activity.
在CFY大鼠中，同时测量了心脏、股内侧肌和肝脏的组织氧化还原状态电位（E0'）以及心率和QRS波幅。观察到，在使用可那康引起代偿性还原作用后，自律性心率和QRS波幅均增加，而在尿素诱导代偿性氧化作用后则出现相反情况。在可那康引起代偿性还原作用后，乙酰胆碱减少，但肾上腺素比在正常E0'值时更强烈地增加心率和QRS波幅。在尿素引起代偿性氧化作用后，乙酰胆碱使心率和QRS波幅降低的幅度明显更小。在这种环境下，肾上腺素使心率降低。基于这些数据，得出以下结论：为实现自律性活动、心脏中负性类型乙酰胆碱和正性类型肾上腺素的作用，相对较低的原始组织E0'值是一个必不可少的背景要素。在控制自律性和交感/副交感作用的机制中，实际且不断变化的组织E0'值也是心脏活动的一个重要调节因素，甚至通过生化氧化还原反馈机制成为调节心脏活动的因素。
