Kjaergaard Thomas, Cvancarova Milada, Steinsvåg Sverre K
Department of Otolaryngology, Head and Neck Surgery, Haukeland University Hospital, Bergen, Norway.
Laryngoscope. 2009 Aug;119(8):1628-32. doi: 10.1002/lary.20505.
The relationship between congestion of the nasal mucosa and subjective nasal obstruction remains poorly defined. Applying the novel Nasal Congestion Index (NCI), we compared subjective nasal obstruction with objective measures for reversible congestion of the nasal mucosa.
A total of 2,523 consecutive patients were included in this cross-sectional study. Eligible subjects were adults referred to the ENT department, Sørlandet Hospital, Kristiansand, Norway, for evaluation of chronic nasal or sleep-related complaints.
Subjects underwent acoustic rhinometry (AR) and peak nasal inspiratory flow (PNIF) at baseline and after decongestion of the nasal mucosa. Based on these registrations, an NCI was calculated for minimal cross-sectional area (MCA), nasal cavity volume (NCV), and PNIF, and employed for quantification of reversible mucosal congestion. Subjective nasal obstruction was measured by nasal obstruction visual analogue scales (NO-VAS). Statistical analyses were based on ANOVA and multiple linear and logistic regression, adjusting for age, gender, body mass index, asthma, allergy, smoking history, and type of planned intervention.
Crude estimates indicated that the NCIs were significantly higher in subjects with severe complaints of nasal obstruction compared with subjects with lesser symptoms (P < .001). These associations were confirmed by linear and logistic regression analyses. NCI for MCA, NCV, and PNIF showed highly significant associations with subjective nasal obstruction (P < .001).
We have clearly demonstrated an association between subjective nasal obstruction and reversible congestion of the nasal mucosa by employing the NCI. The measure has proven to be useful for evaluating patients with complaints of nasal obstruction.
鼻黏膜充血与主观鼻阻塞之间的关系仍未明确界定。应用新型鼻充血指数(NCI),我们将主观鼻阻塞与鼻黏膜可逆性充血的客观测量指标进行了比较。
本横断面研究共纳入2523例连续患者。符合条件的受试者为转诊至挪威克里斯蒂安桑市索兰德医院耳鼻喉科,因慢性鼻部或睡眠相关主诉接受评估的成年人。
受试者在基线时以及鼻黏膜减充血后接受鼻声反射(AR)和鼻吸气峰流量(PNIF)测量。基于这些记录,计算出最小横截面积(MCA)、鼻腔容积(NCV)和PNIF的NCI,并用于量化可逆性黏膜充血。主观鼻阻塞通过鼻阻塞视觉模拟量表(NO-VAS)进行测量。统计分析基于方差分析以及多元线性和逻辑回归,并对年龄、性别、体重指数、哮喘、过敏、吸烟史和计划干预类型进行了校正。
粗略估计表明,与症状较轻的受试者相比,严重鼻阻塞主诉的受试者NCI显著更高(P < 0.001)。线性和逻辑回归分析证实了这些关联。MCA、NCV和PNIF的NCI与主观鼻阻塞显示出高度显著的关联(P < 0.001)。
我们通过使用NCI明确证明了主观鼻阻塞与鼻黏膜可逆性充血之间的关联。该测量方法已被证明对评估有鼻阻塞主诉的患者有用。