Kogan E A, Strizhakov L A, Namestnikova O G, Krivosheev O G, Semenkova E N
Arkh Patol. 2009 Mar-Apr;71(2):29-32.
The Churg-Strauss syndrome is a systemic vasculitis, the manifestations of which are asthma, eosinophilia, pulmonary infiltrates, poly- and mononeuropathy, polyserositis. Along with nodular polyarteritis and nonspecific aortoarteritis, the Churg-Strauss syndrome belongs to a group of systemic vasculitis, in the clinical picture of which cardiac lesion is recognized as one of the leading visceral manifestations and may be a common cause of fatal outcomes. In the Churg-Strauss syndrome, cardiac pathology may be associated with the involvement of the endocardium, myocardium, and pericardium. The paper describes a case showing the poor course of the disease in a young female patient in whom the heart is involved in a pathological process with the development of severe heart failure, resulting in death. There is a rare concomitance of diffuse myocardial damage, coronary lesion, and valvular pathology - eosinophilic endocarditis. The diagnosis has been verified on the basis of the data of clinical and additional studies and the results of microscopic studies. The data available in the Russian and foreign literature on cardiac pathology in patients with the Churg-Strauss syndrome are analyzed.
变应性肉芽肿性血管炎是一种系统性血管炎，其表现为哮喘、嗜酸性粒细胞增多、肺部浸润、多神经病变和单神经病变、多发性浆膜炎。与结节性多动脉炎和非特异性主动脉动脉炎一样，变应性肉芽肿性血管炎属于系统性血管炎组，在其临床表现中，心脏病变被认为是主要的内脏表现之一，可能是致命后果的常见原因。在变应性肉芽肿性血管炎中，心脏病理可能与心内膜、心肌和心包受累有关。本文描述了一例年轻女性患者病情不佳的病例，该患者心脏参与病理过程，发展为严重心力衰竭，最终死亡。存在罕见的弥漫性心肌损伤、冠状动脉病变和瓣膜病理——嗜酸性粒细胞性心内膜炎并存情况。诊断已根据临床和附加研究数据以及显微镜研究结果得到证实。对俄罗斯和国外文献中有关变应性肉芽肿性血管炎患者心脏病理的现有数据进行了分析。
