药物性肾上腺切除术后大鼠的血浆促肾上腺皮质激素
Plasma ACTH in rats following medical adrenalectomy.
作者信息
Mims R B, Beard W
出版信息
J Natl Med Assoc. 1977 Mar;69(3):145-7.
We have previously reported that surgically adrenalectomized nonstressed rats showed delayed secretion of the expected increase in plasma ACTH concentrations following adrenalectomy.(1) However, increased plasma ACTH concentrations were always detected when these animals were subjected to severe stress, and their responsiveness increased again seven days or more following surgical adrenalectomy. We are now reporting similar results which were obtained following prolonged systemic glucocorticoid administration (medical adrenalectomy) in similar groups of rats.
我们之前报道过，手术切除肾上腺的非应激大鼠在肾上腺切除术后，血浆促肾上腺皮质激素（ACTH）浓度预期升高的分泌出现延迟。（1）然而，当这些动物受到严重应激时，总能检测到血浆ACTH浓度升高，并且在手术切除肾上腺七天或更长时间后其反应性再次增强。我们现在报告在相似组别的大鼠中长期全身性给予糖皮质激素（药物性肾上腺切除）后获得的类似结果。
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