罗马尼亚大肠埃希菌和肺炎克雷伯菌临床分离株中质粒介导喹诺酮耐药qnr样基因的鉴定
Identification of plasmid-mediated quinolone resistance qnr-like genes in Romanian clinical isolates of Escherichia coli and Klebsiella pneumoniae.
作者信息
Usein Codruţa-Romaniţa, Palade Andi-Marian, Tatu-Chiţoiu Dorina, Ciontea Simona, Ceciu Stefania, Nica Maria, Damian Maria
机构信息
Molecular Microbiology Laboratory, National Institute of Research-Development for Microbiology and Immunology Cantacuzino.
出版信息
Roum Arch Microbiol Immunol. 2009 Jan-Mar;68(1):55-7.
A collection of putative ESBL-producing Escherichia coli (119 isolates) and Klebsiella pneumoniae (122 isolates) originating from extraintestinal human specimens was screened for qnrA, qnrB, and qnrS-like genes by PCR. Seven K. pneumoniae isolates, which were resistant to ciprofloxacin, were detected as carrying qnrA1-like genes, while one K. pneumoniae and one E. coli isolate were positive for qnrS-like determinant. The latter isolates were susceptible to ciprofloxacin. This is the first study identifying qnr-like genes in our area. Further studies are needed to document the contribution of the plasmid mediated quinolone resistance to the increase in bacterial resistance to fluoroquinolones in Romania.
对一组来自人类肠外标本的推测产超广谱β-内酰胺酶（ESBL）的大肠杆菌（119株分离菌）和肺炎克雷伯菌（122株分离菌）通过聚合酶链反应（PCR）筛查qnrA、qnrB和qnrS样基因。七株对环丙沙星耐药的肺炎克雷伯菌分离菌被检测出携带qnrA1样基因，而一株肺炎克雷伯菌和一株大肠杆菌分离菌的qnrS样决定簇呈阳性。后一种分离菌对环丙沙星敏感。这是在我们地区首次鉴定出qnr样基因的研究。需要进一步研究来证明质粒介导的喹诺酮耐药性对罗马尼亚细菌对氟喹诺酮耐药性增加的作用。
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