在辣椒素预处理的大鼠中，2-脱氧-D-葡萄糖（2-DG）诱导的胃酸分泌增加受到损害。

2-Deoxy-D-glucose (2-DG)-induced increase in gastric acid secretion is impaired in capsaicin-pretreated rats.

作者信息

Evangelista S, Santicioli P, Maggi C A

机构信息

Pharmacology Department, Menarini Pharmaceuticals, Florence, Italy.

出版信息

Adv Exp Med Biol. 1991;298:301-6. doi: 10.1007/978-1-4899-0744-8_27.

DOI:10.1007/978-1-4899-0744-8_27

PMID:1950790

Abstract

This study investigated the increase in gastric acid secretion induced by intravenous administration of 2-deoxy-D-glucose (2-DG; 60 mg kg-1), insulin (5 U kg-1) or by electrical stimulation of the vagus nerve (1 mA, 1 ms, 3 Hz) in urethane-anesthetized rats pretreated when newborn with either capsaicin or the vehicle. The secretory response to 2-DG was substantially reduced in the capsaicin pretreated rats, while those induced by electrical vagal stimulation or insulin were unaffected. These findings suggest that capsaicin-sensitive fibers are involved in the afferent branch of the reflex response activated by 2-DG to stimulate gastric acid secretion.

摘要

本研究调查了在新生时用辣椒素或赋形剂预处理的乌拉坦麻醉大鼠中，静脉注射2-脱氧-D-葡萄糖（2-DG；60mg/kg）、胰岛素（5U/kg）或通过迷走神经电刺激（1mA，1ms，3Hz）诱导的胃酸分泌增加情况。辣椒素预处理的大鼠对2-DG的分泌反应显著降低，而迷走神经电刺激或胰岛素诱导的反应不受影响。这些发现表明，辣椒素敏感纤维参与了2-DG激活的反射反应的传入分支，以刺激胃酸分泌。