在辣椒素预处理的大鼠中，2-脱氧-D-葡萄糖诱导的胃分泌增加受到损害。
Increase in gastric secretion induced by 2-deoxy-D-glucose is impaired in capsaicin pretreated rats.
作者信息
Evangelista S, Santicioli P, Maggi C A, Meli A
机构信息
Pharmacology Department, Menarini Pharmaceuticals, Firenze, Italy.
出版信息
Br J Pharmacol. 1989 Sep;98(1):35-7. doi: 10.1111/j.1476-5381.1989.tb16858.x.
Abstract
Gastric acid secretion was determined following intravenous administration of 2-deoxy-D-glucose (2-DG; 60 mg kg-1) or electrical stimulation of the vagus nerve in urethane-anaesthetized rats pretreated when newborn with either capsaicin or the vehicle. The secretory response to 2-DG was substantially reduced in the capsaicin pretreated rats, while that induced by electrical vagal stimulation (1 mA, 1 ms. 3 Hz) was unaffected. These results suggest that capsaicin-sensitive fibres are involved in the afferent branch of the reflex response activated by 2-DG to stimulate gastric acid secretion.
摘要
在新生时用辣椒素或赋形剂预处理的乌拉坦麻醉大鼠中，静脉注射2-脱氧-D-葡萄糖（2-DG；60mg/kg）或电刺激迷走神经后，测定胃酸分泌。辣椒素预处理的大鼠对2-DG的分泌反应显著降低，而电刺激迷走神经（1mA，1ms，3Hz）诱导的反应不受影响。这些结果表明，辣椒素敏感纤维参与了2-DG激活的刺激胃酸分泌的反射反应的传入分支。
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