Vinnik C A, Jacob S W
Department of Surgery, Oregon Health Sciences University.
Aesthetic Plast Surg. 1991 Fall;15(4):327-37. doi: 10.1007/BF02273881.
Dimethylsulfoxide (DMSO) has been in clinical use since the early 1960s. In 1967 the discovery that DMSO can greatly reduce ischemia in experimental pedicle flaps stimulated its use in plastic surgery by the authors since 1976. In 1987 its ability to soften collagen, thus permitting degrees of immediate intraoperative tissue expansion hitherto unknown, was applied clinically for the first time. Evolving use of topical 70% DMSO alone, in combination with intravenous DMSO, and intravenous DMSO alone with greater efficacy is discussed. Cases of intraoperative tissue expansion for large lesion excision and use in abdominoplasty to maximize skin resection are discussed. In breast reconstruction, maximal tissue expansion in minutes with immediate placement of large permanent prostheses ends the delay of reconstruction and problems of chronic tissue expander capsule formation and gives this technique a clear advantage over other reconstructive techniques.
自20世纪60年代初以来，二甲基亚砜（DMSO）就已应用于临床。1967年，有研究发现DMSO能大幅减轻实验性带蒂皮瓣的缺血情况，自1976年起作者们便开始在整形外科中使用它。1987年，其软化胶原蛋白的能力首次在临床上得到应用，从而实现了此前未知程度的术中即时组织扩张。本文讨论了单独使用70%外用DMSO、联合静脉注射DMSO以及单独静脉注射DMSO且疗效更佳的不断发展的应用情况。还讨论了在大病灶切除术中进行术中组织扩张以及在腹部整形术中用于最大化皮肤切除的案例。在乳房重建中，通过即时植入大型永久性假体在数分钟内实现最大程度的组织扩张，消除了重建延迟以及慢性组织扩张器包膜形成的问题，使该技术相较于其他重建技术具有明显优势。
