局部应用二甲基亚砜治疗手术皮瓣效果改善
Improved outcome of surgical flaps treated with topical dimethylsulfoxide.
作者信息
Rand-Luby L, Pommier R F, Williams S T, Woltering E A, Small K A, Fletcher W S
机构信息
Department of Surgery, Oregon Health Sciences University, Portland, USA.
出版信息
Ann Surg. 1996 Oct;224(4):583-9; discussion 589-90. doi: 10.1097/00000658-199610000-00016.
OBJECTIVE
The objective of this study was to analyze the effect of dimethylsulfoxide (DMSO) on skin flap viability.
BACKGROUND
Dimethylsulfoxide has been shown to decrease necrosis of random skin flaps in the rat model, but no human studies have been performed. The authors performed a randomized, prospective study on the effect of DMSO on skin flap viability in patients undergoing mastectomy and inguinal lymphadenectomy.
METHODS
Twenty-four patients had topical 60% DMSO applied to their flaps every 4 hours x 10 days after operation and 27 patients had operation alone. The maximum area of flap ischemia was traced by a masked observer and measured by cut and weigh technique. Significance of differences between the treatment and control group was determined by Student's test.
RESULTS
The mean area of ischemia for the DMSO group was 16.33 U versus 44.93 U for the control group. This difference was statistically significant (p = 0.01).
CONCLUSIONS
The authors conclude that topical application of DMSO reduces skin flap ischemia in humans and recommend its use after operation in which skin flaps are created.
目的
本研究的目的是分析二甲基亚砜（DMSO）对皮瓣存活能力的影响。
背景
在大鼠模型中，二甲基亚砜已被证明可减少随意皮瓣的坏死，但尚未进行人体研究。作者对接受乳房切除术和腹股沟淋巴结清扫术的患者进行了一项关于二甲基亚砜对皮瓣存活能力影响的随机前瞻性研究。
方法
24例患者在术后每4小时在皮瓣上局部应用60%二甲基亚砜，共10天，27例患者仅接受手术。由一名不知情的观察者追踪皮瓣缺血的最大面积，并采用切割称重技术进行测量。治疗组和对照组之间差异的显著性通过学生检验确定。
结果
二甲基亚砜组的平均缺血面积为16.33单位，而对照组为44.93单位。这一差异具有统计学意义（p = 0.01）。
结论
作者得出结论，局部应用二甲基亚砜可减少人体皮瓣缺血，并建议在进行皮瓣手术术后使用。
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