Department of Pathology, Ege University School of Medicine, Izmir, Turkey.
Neuropathology. 2010 Feb 1;30(1):71-5. doi: 10.1111/j.1440-1789.2009.01031.x. Epub 2009 Jun 7.
We report a rare case of ependymoma with vacuolar features, signet cells, pigmentation and numerous Rosenthal fibers arising in the fourth ventricle of a 35-year-old woman. The tumor was composed of cells with cytoplasmic vacuoles, signet cells and clear cells. The clear cells were compactly arranged resembling oligodendroglioma. Pseudovascular and ependymal rosettes were observed only in focal areas. Additionally, some tumor cells contained brown cytoplasmic pigment, which was histochemically compatible with lipofuscin and neuromelanin. On immunohistochemical examination, the tumor cells were positive for S100, glial fibrillary acidic protein and vimentin, and negative for synaptophysin, cytokeratin, neurofilament and HMB45. Epithelial membrane antigen staining showed dot-like and small vesicular reactivity. The case is presented to increase familiarity with these extraordinary variants of ependymoma.
我们报告一例罕见的第四脑室 35 岁女性的具有空泡特征、印戒细胞、色素沉着和大量 Rosenthal 纤维的室管膜瘤。肿瘤由具有细胞质空泡、印戒细胞和透明细胞的细胞组成。透明细胞排列紧密，类似于少突胶质细胞瘤。假血管和室管膜花环仅在局灶区域观察到。此外，一些肿瘤细胞含有棕色细胞质色素，组织化学上与脂褐素和神经黑色素相容。免疫组织化学检查显示，肿瘤细胞 S100、神经胶质纤维酸性蛋白和波形蛋白阳性，突触素、细胞角蛋白、神经丝和 HMB45 阴性。上皮膜抗原染色呈点状和小泡状反应。本病例旨在增加对这些不同寻常的室管膜瘤变异体的认识。
