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经导管线圈栓塞治疗大肠大出血的长期随访。

Long term follow-up of transcatheter coil embolotherapy for major colonic haemorrhage.

机构信息

Academic Surgical Unit, University of Hull, Castle Hill Hospital, Cottingham, UK.

出版信息

Colorectal Dis. 2010 Oct;12(10):1013-7. doi: 10.1111/j.1463-1318.2009.01906.x.

Abstract

AIM

Therapeutic angiography with embolization is fast becoming the preferred treatment modality for major bleeding in the lower gastrointestinal (LGI) tract. The aim of this study was to determine the long term outcome and complications of percutaneous coil embolization (PCE) and its efficacy as definitive therapy in patients with major LGI bleeding.

METHODS

All patients presenting to our institution with a haemodynamically significant LGI tract bleed between 1995 and 2001 that were unresponsive to conservative measures were considered for emergency angiography and coil embolization where appropriate. The outcome of these individuals was determined by case note review and telephone interview.

RESULTS

There were 20 patients (11 females) with a mean follow-up period 72 months, mean age was 67 years. All underwent PCE following positive angiogram. The most common site of bleeding was the right colon (40%); haemostasis was successfully achieved in 16 (80%) patients. Five of the 20 patients died within 30 days of the intervention, three following PCE and two following surgery. None of the mortality following PCE was considered procedure related. On long term follow-up four patients required readmission to hospital for further LGI bleeds at 1, 2, 12 and 16 months respectively. Ischaemic complications occurred in 23%.

CONCLUSION

Superselective embolization as the primary technique for the treatment of haemodynamically significant LGI bleeding is an effective, feasible and safe technique. Long term follow-up in our series up to 72 months has shown that it should be considered as both a primary and potentially definitive treatment for life threatening LGI bleeds.

摘要

目的

经导管动脉内栓塞治疗术已迅速成为治疗下消化道(LGI)大出血的首选治疗方法。本研究旨在确定经皮线圈栓塞术(PCE)的长期疗效和并发症,以及其作为 LGI 大出血患者确定性治疗的疗效。

方法

1995 年至 2001 年间,我们医院对所有因下消化道大出血而出现血流动力学不稳定且对保守治疗无反应的患者进行了紧急血管造影和线圈栓塞术。通过病历回顾和电话访谈确定这些患者的结局。

结果

共有 20 名(11 名女性)患者,平均随访时间为 72 个月,平均年龄为 67 岁。所有患者均在血管造影阳性后行 PCE。最常见的出血部位是右结肠(40%);16 例(80%)患者成功止血。20 例患者中有 5 例在干预后 30 天内死亡,其中 3 例死于 PCE,2 例死于手术。没有一例 PCE 相关的死亡率。长期随访中,4 例患者分别在 1、2、12 和 16 个月时因进一步的 LGI 出血再次入院。缺血性并发症发生率为 23%。

结论

作为治疗血流动力学不稳定 LGI 大出血的主要技术,超选择性栓塞术是一种有效、可行和安全的技术。我们的系列研究最长随访时间达 72 个月,表明它应被视为危及生命的 LGI 出血的主要治疗方法,也可能是确定性治疗方法。

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