Academic Unit of Bone Metabolism, Northern General Hospital, University of Sheffield, Sheffield, UK.
Clin Endocrinol (Oxf). 2010 Mar;72(3):320-7. doi: 10.1111/j.1365-2265.2009.03606.x. Epub 2009 Apr 17.
Bone turnover decreases from adolescence into adulthood, but does not reach a nadir until the fourth decade. Biochemical markers of bone turnover reflect different processes before and after peak bone mass, so hormonal influences on bone turnover may differ before and after peak bone mass.
To describe the changes in bone turnover and hormones relevant to bone metabolism from adolescence into adulthood, and to identify which hormones correlate with bone turnover before and after peak bone mass.
DESIGN/PARTICIPANTS: Two measurements of bone turnover markers and hormones were obtained 5-9 years apart in 116 healthy males and females recruited from secondary schools and general practices. Correlations were examined cross-sectionally and longitudinally.
Dehydroepiandrosterone sulphate (DHEAS) correlated negatively with bone turnover cross-sectionally and longitudinally (r-0.59 to -0.69) in males and females under the age of 25 years. IGF-1 correlated positively with aminoterminal propeptide of type I procollagen (PINP) cross-sectionally and longitudinally (r 0.35) in women over the age of 25 years. After correction for change in BMI, there were significant longitudinal correlations between DHEAS and bone turnover in women under 25 years (r-0.62, -0.66) and IGF-1 and PINP in women over 25 years (r 0.56).
We have described changes in bone turnover and hormones from adolescence into adulthood. Dehydroepiandrosterone sulphate correlates with bone turnover before peak bone mass which may represent a direct effect on bone metabolism or the role of dehydroepiandrosterone sulphate as a substrate for conversion to other sex steroids. IGF-1 is correlated with aminoterminal propeptide of type I procollagen in women after peak bone mass, which may reflect an influence on cortical modelling.
骨转换从青春期进入成年期逐渐减少，但直到第四十年才达到最低点。骨转换的生化标志物反映了峰值骨量前后不同的过程，因此激素对骨转换的影响可能在峰值骨量前后有所不同。
描述从青春期到成年期骨代谢相关的骨转换和激素的变化，并确定哪些激素与峰值骨量前后的骨转换相关。
设计/参与者：从中学和普通诊所招募了 116 名健康男性和女性，他们在 5-9 年内进行了两次骨转换标志物和激素测量。分别进行了横断面和纵向相关性分析。
在 25 岁以下的男性和女性中，硫酸脱氢表雄酮（DHEAS）与骨转换呈负相关（横断面和纵向 r 值分别为-0.59 至-0.69）。在 25 岁以上的女性中，胰岛素样生长因子 1（IGF-1）与 I 型前胶原氨基端前肽（PINP）呈正相关（横断面和纵向 r 值分别为 0.35）。在纠正 BMI 变化后，25 岁以下的女性中 DHEAS 和骨转换之间存在显著的纵向相关性（r 值分别为-0.62 和-0.66），25 岁以上的女性中 IGF-1 和 PINP 之间存在显著的纵向相关性（r 值为 0.56）。
我们描述了从青春期到成年期骨转换和激素的变化。DHEAS 与峰值骨量前的骨转换相关，这可能代表了对骨代谢的直接影响，或 DHEAS 作为其他性激素转化的底物的作用。IGF-1 与峰值骨量后女性的 I 型前胶原氨基端前肽相关，这可能反映了其对皮质模型的影响。
