Patalong-Wójcik Martyna, Golara Anna, Zając Katarzyna, Sokołowska Alicja, Kozłowski Mateusz, Tołoczko-Grabarek Aleksandra, Krzyścin Mariola, Brodowska Agnieszka, Janiec Agnieszka, Myszka Aleksandra, Cymbaluk-Płoska Aneta, Sowińska-Przepiera Elżbieta
Department of Endocrinology, Metabolic and Internal Diseases, Pomeranian Medical University in Szczecin, UniiLubelskiej 1, 71-252 Szczecin, Poland.
Department of Reconstructive Surgery and Gynecological Oncology, Pomeranian Medical University in Szczecin, Al. Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland.
Biomedicines. 2023 May 29;11(6):1574. doi: 10.3390/biomedicines11061574.
Osteoporosis is a disease characterised by a reduction in bone strength due to increased porosity and impaired mineralisation. In our study, we investigated whether muscle strength and mass exert a significant effect on bone mineral density in young adult women. We also tested whether sclerostin can be used as an indicator in the assessment of bone mineralisation. The study included 111 patients. All patients had their bone mineral density determined in the L1-L4 section of the lumbar spine and in the whole skeleton. The parameters of fat mass (FM), lean body mass (LBM) and visceral fat mass (VF) were also determined. Metabolic activity of osteocytes was assessed by measuring the serum sclerostin concentration. There was a statistically significant association of both hands' muscle strength with all parameters expressing bone mineralisation. A statistically significant relationship was also obtained between BMD L1-L4 and the body mass components (FM, LBM). Sclerostin levels in the study did not differ between groups with normal and reduced bone mineral density. Muscle strength assessment may be a potential exponent of reduced bone mineral density, also used clinically in young adult women. The utility of sclerostin in the clinical assessment of bone mineralisation has not been demonstrated.
骨质疏松症是一种由于骨孔隙率增加和矿化受损导致骨强度降低的疾病。在我们的研究中，我们调查了肌肉力量和质量是否对年轻成年女性的骨矿物质密度有显著影响。我们还测试了硬化素是否可作为评估骨矿化的指标。该研究纳入了111名患者。所有患者均测定了腰椎L1-L4节段及全身骨骼的骨矿物质密度。还测定了脂肪量（FM）、瘦体重（LBM）和内脏脂肪量（VF）参数。通过测量血清硬化素浓度评估骨细胞的代谢活性。双手肌肉力量与所有表达骨矿化的参数之间存在统计学显著关联。L1-L4节段的骨密度与身体质量成分（FM、LBM）之间也获得了统计学显著关系。研究中骨矿物质密度正常和降低的组之间硬化素水平没有差异。肌肉力量评估可能是骨矿物质密度降低的一个潜在指标，在年轻成年女性的临床中也可使用。硬化素在骨矿化临床评估中的效用尚未得到证实。
