Wang Yingmei, Xue Fengxia, Broaddus Russell R, Tao Xia, Xie Su-su, Zhu Yanbin
Department of Obstetrics and Gynecology, General Hospital of Tianjin Medical University, Tianjin, China.
Int J Gynecol Cancer. 2009 May;19(4):651-6. doi: 10.1111/IGC.0b013e3181a12fb9.
To study the clinicopathological characteristics of Lynch syndrome-associated endometrial carcinoma in China.
Twenty-seven patients who fulfilled Amsterdam criteria II were classified as having Lynch syndrome-associated endometrial carcinoma (group A), and 331 patients without a family history of cancer were classified as having sporadic endometrial carcinoma (group B).
There were 81 malignancies in 27 families with Lynch syndrome-associated endometrial carcinoma, including colorectal cancer (24.7%), endometrial carcinoma (21.0%), and liver (12.3%), stomach (9.9%), lung (6.2%), and breast (6.2%) cancers. Mean age at the time of diagnosis was 49.7 years in group A and 56.3 years in group B (P = 0.004). Second primary cancers occurred in 33.3% of patients in group A and 5.1% in group B (P = 0.000). The most common second primary cancers were colorectal cancer (44%) and ovarian cancer (22%). The percentage of obese patients was higher in group A (P= 0.013). There was no difference between the 2 groups in incidence of diabetes mellitus or hypertension or in histological type and International Federation of Gynecology and Obstetrics stage. The 5-year survival rates for groups A and B were 96.2% and 79.6%, respectively. Prognosis for group A was better than for group B (P = 0.045).
Some clinicopathological features of Lynch syndrome-associated endometrial carcinoma, such as early onset and multiple primary carcinomas are similar in the Chinese and American/European populations. However, the Chinese population had a unique family cancer distribution that included lung and breast cancers. Well-differentiated grade and good prognosis imply better biobehavior of Lynch syndrome-associated endometrial carcinoma in the Chinese population.
研究中国林奇综合征相关子宫内膜癌的临床病理特征。
27例符合阿姆斯特丹标准Ⅱ的患者被归类为林奇综合征相关子宫内膜癌（A组），331例无癌症家族史的患者被归类为散发性子宫内膜癌（B组）。
27个林奇综合征相关子宫内膜癌家族中有81例恶性肿瘤，包括结直肠癌（24.7%）、子宫内膜癌（21.0%）、肝癌（12.3%）、胃癌（9.9%）、肺癌（6.2%）和乳腺癌（6.2%）。A组诊断时的平均年龄为49.7岁，B组为56.3岁（P = 0.004）。A组33.3%的患者发生了第二原发性癌症，B组为5.1%（P = 0.000）。最常见的第二原发性癌症是结直肠癌（44%）和卵巢癌（22%）。A组肥胖患者的比例更高（P = 0.013）。两组在糖尿病或高血压发病率、组织学类型或国际妇产科联盟分期方面无差异。A组和B组的5年生存率分别为96.2%和79.6%。A组的预后优于B组（P = 0.045）。
林奇综合征相关子宫内膜癌的一些临床病理特征，如发病早和多原发性癌，在中国人群和欧美人群中相似。然而，中国人群有独特的家族性癌症分布，包括肺癌和乳腺癌。高分化等级和良好预后意味着林奇综合征相关子宫内膜癌在中国人群中具有更好的生物学行为。
