Zhang Yanrong, Li Wenjing, Yan Tianwei, Lu Chengfa, Zhou Xiang, Huang Yan
Department of Medical Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
J Huazhong Univ Sci Technolog Med Sci. 2009 Jun;29(3):387-90. doi: 10.1007/s11596-009-0325-8. Epub 2009 Jun 10.
This study evaluated the value of high-frequency ultrasonograpy for early detection of dorsal artery of foot in patients with type 2 diabetes mellitus (MD). Eighty subjects including 40 patients with type 2 MD (T2DM group) and 40 healthy volunteers (NC group) were recruited. The intima-media thickness (IMT), the inner diameter and the perfusion of dorsal artery of foot were measured by using high-frequency ultrasonograpy. Meanwhile, the parameters of vascular elasticity, including stiffness parameter (beta), pressure-strain elastic modulus (Erho), arterial compliance (AC), augment index (AI), and pulse wave conducting velocity (PWVbeta) were detected by means of echo-tracking technique. The results showed that no significant difference was found in the IMT, systolic diameter (Ds), diastolic diameter (Dd) and peak systolic velocity (PSV) between T2DM and NC groups. Erho and PWVbeta were increased, and AC was decreased in T2DM group as compared with those in NC group with the differences being significant (P<0.05 for all). There was no significant difference in beta and AI between T2DM and NC groups. It was concluded that high-frequency ultrasonography in combination with echo-tracking technique is sensitive and non-invasive, and can be used for early detection of sclerosis of the lower extremity artery in patients with type 2 MD.
本研究评估了高频超声检查对2型糖尿病（MD）患者足背动脉早期检测的价值。招募了80名受试者，包括40例2型MD患者（T2DM组）和40名健康志愿者（NC组）。使用高频超声测量足背动脉的内膜中层厚度（IMT）、内径和灌注情况。同时，采用回声跟踪技术检测血管弹性参数，包括硬度参数（β）、压力应变弹性模量（Erho）、动脉顺应性（AC）、增强指数（AI）和脉搏波传导速度（PWVbeta）。结果显示，T2DM组和NC组在IMT、收缩期直径（Ds）、舒张期直径（Dd）和收缩期峰值流速（PSV）方面无显著差异。与NC组相比，T2DM组的Erho和PWVbeta升高，AC降低，差异均有统计学意义（均P<0.05）。T2DM组和NC组在β和AI方面无显著差异。结论是，高频超声联合回声跟踪技术敏感且无创，可用于2型MD患者下肢动脉硬化的早期检测。
