Department of Ophthalmology & Vision Sciences, University of California Davis, Sacramento, California, USA.
Br J Ophthalmol. 2010 Jul;94(7):815-20. doi: 10.1136/bjo.2008.151852. Epub 2009 Jun 9.
Pterygium is an ocular surface disease of humans attributed to chronic ultraviolet-B exposure. Clinically, the condition involves invasive centripetal growth with associated inflammation and neovascularisation. Previous clinical studies focused primarily on the clinical characteristics and surgical management of pterygia and, because of this, the pathogenesis of pterygia remains incompletely understood. However, considerable progress in this area has been achieved, providing additional insight into this complex disease. This recent evidence implicates antiapoptotic mechanisms, immunological mechanisms, cytokines, growth factors, extracellular matrix modulators, genetic factors, viral infections and other possible causative factors. Limited investigation regarding differences in pathogenesis of primary and recurrent pterygia has been performed. We summarise many of these recent discoveries concerning the pathogenesis of pterygia and describe reported differences between primary and recurrent pterygia.
翼状胬肉是一种人类眼表面疾病，归因于慢性紫外线-B 暴露。临床上，这种疾病涉及到具有相关炎症和新生血管形成的中心向侵袭性生长。以前的临床研究主要集中在翼状胬肉的临床特征和手术治疗上，因此，翼状胬肉的发病机制仍不完全清楚。然而，在这一领域已经取得了相当大的进展，为这种复杂的疾病提供了更多的见解。这些最近的证据表明了抗凋亡机制、免疫机制、细胞因子、生长因子、细胞外基质调节剂、遗传因素、病毒感染和其他可能的致病因素。对于原发性和复发性翼状胬肉发病机制的差异，相关的研究非常有限。我们总结了许多关于翼状胬肉发病机制的这些最新发现，并描述了原发性和复发性翼状胬肉之间的报告差异。
