Uçakhan Omür O, Kanpolat Ayfer, Elgün Serenay, Durak Ilker
Department of Ophthalmology, Ankara University School of Medicine, Ankara, Turkey.
Ophthalmologica. 2009;223(1):41-6. doi: 10.1159/000167020. Epub 2008 Nov 4.
To evaluate the role of light-induced oxidative mechanisms in the pathogenesis of primary pterygium.
Pterygium specimens were obtained from 18 eyes of 18 patients undergoing pterygial removal (group A), and normal conjunctival specimens were obtained from 18 eyes of 18 patients undergoing cataract surgery (group B). In all specimens, malondialdehyde (MDA) levels, superoxide dismutase (SOD) and catalase (CAT) activities were studied and compared.
In group A, the mean SOD activity was lower, and the mean MDA level was higher when compared to group B. However, these differences did not reach clinical significance (p > 0.05). On the other hand, the mean CAT activity was statistically significantly higher in group A when compared to controls (p = 0.017).
This preliminary study indicates that oxidative mechanisms seem to play a role in the pathogenesis of pterygium. These mechanisms are apparently activated by ultraviolet irradiation. Further studies are required to establish the role of oxidative mechanisms in the pathogenesis of primary or recurrent pterygia.
评估光诱导氧化机制在原发性翼状胬肉发病机制中的作用。
从18例接受翼状胬肉切除术患者的18只眼中获取翼状胬肉标本（A组），从18例接受白内障手术患者的18只眼中获取正常结膜标本（B组）。研究并比较所有标本中的丙二醛（MDA）水平、超氧化物歧化酶（SOD）和过氧化氢酶（CAT）活性。
与B组相比，A组的平均SOD活性较低，平均MDA水平较高。然而，这些差异未达到临床显著性（p>0.05）。另一方面，与对照组相比，A组的平均CAT活性在统计学上显著更高（p = 0.017）。
这项初步研究表明氧化机制似乎在翼状胬肉的发病机制中起作用。这些机制显然是由紫外线照射激活的。需要进一步研究以确定氧化机制在原发性或复发性翼状胬肉发病机制中的作用。
