月经周期长度与抗苗勒管激素及促卵泡生成素的关系
Menstrual cycle length in relation to antimüllerian hormone and follicle-stimulating hormone.
作者信息
Rashidi Batool Hossein, Abediasl Zhila, Tehraninejad Ensiyeh Shahrokh, Shariat Mamak, Mahdavi Atossa
机构信息
Vali-e-Asr Reproductive Health Research Center, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
J Reprod Med. 2009 May;54(5):315-8.
OBJECTIVE
To find a relationship between serum antimüllerian hormone (AMH) and follicle-stimulating hormone (FSH) levels in women with regular menstruation.
STUDY DESIGN
A cross-sectional study was conducted on 71 women with male factor infertility. Serum level of AMH and FSH and mean menstrual cycle length (MCL) were measured. The study aimed to find the correlation between serum AMH and FSH levels in normal menstrual cycles.
RESULTS
Our study included 71 women. Of them, 53 had an MCL of 25-35 days (group A) and 18 women had an MCL > 35 days (group B). The mean AMH in group A and group B differed significantly (4.11 +/- 3.4 ng/L, 7.42 +/- 4.34 ng/L, respectively; p < 0.008). In group A, reverse correlation between FSH and AMH was found (r = -0.32, p < 0.03).
CONCLUSION
AMH level had significant difference with FSH in patients of group A who had FSH > or = 12 IU/L or FSH < 12 IU/L (1.02 +/- 0.7, 4.8 +/- 3.5 ng/L, respectively; p < 0.02). Serum AMH level with threshold of 2.2 ng/L had sensitivity of 75% and specificity of 82% in predicting FSH > or = 12 IU/L on the third day of menstrual cycle.
目的
探寻月经规律女性血清抗苗勒管激素（AMH）与促卵泡生成素（FSH）水平之间的关系。
研究设计
对71例男性因素不孕的女性进行横断面研究。测定血清AMH、FSH水平及平均月经周期长度（MCL）。该研究旨在找出正常月经周期中血清AMH与FSH水平之间的相关性。
结果
我们的研究纳入了71名女性。其中，53名女性的MCL为25 - 35天（A组），18名女性的MCL > 35天（B组）。A组和B组的平均AMH有显著差异（分别为4.11±3.4 ng/L、7.42±4.34 ng/L；p < 0.008）。在A组中，发现FSH与AMH呈负相关（r = -0.32，p < 0.03）。
结论
在FSH≥12 IU/L或FSH < 12 IU/L的A组患者中，AMH水平与FSH有显著差异（分别为1.02±0.7、4.8±3.5 ng/L；p < 0.02）。血清AMH水平阈值为2.2 ng/L时，在预测月经周期第3天FSH≥12 IU/L方面，敏感性为75%，特异性为82%。
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