Koller Michael F, Schmid Martin, Iten Peter X, Vonlanthen Bruno, Bär Walter
Institute of Legal Medicine, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.
Leg Med (Tokyo). 2009 Sep;11(5):229-33. doi: 10.1016/j.legalmed.2009.04.003. Epub 2009 Jun 10.
A 52-year-old man was found dead in his bed. He had financial and psychosocial problems like separation from his wife and children or unemployment due to alcoholism. Under treatment of disulfiram he was presently abstinent from alcohol. As he had suffered from epileptic seizures and dizziness, he received valproic acid and the vasodilator naftidrofuryl, respectively. Autopsy showed no morphologic cause of death. Chemical analysis of blood revealed concentrations for valproic acid and disulfiram in the therapeutic and above the therapeutic range but far below the lethal level, respectively. No ethanol was found. However, the very high concentration of 7500 microg/L naftidrofuryl in whole blood was considered as cause of death, and the most probable manner of death seemed to be suicide. To our knowledge, this is the first reported case of a fatal poisoning with naftidrofuryl.
一名52岁男子被发现死在床上。他存在经济和社会心理问题，比如与妻子和孩子分居，或因酗酒而失业。在接受双硫仑治疗期间，他目前已戒酒。由于他曾患有癫痫发作和头晕，分别接受了丙戊酸和血管扩张剂萘呋胺酯的治疗。尸检未发现形态学上的死因。血液化学分析显示，丙戊酸和双硫仑的浓度分别处于治疗范围和高于治疗范围，但远低于致死水平。未检测到乙醇。然而，全血中萘呋胺酯的浓度高达7500微克/升，被认为是死因，最可能的死亡方式似乎是自杀。据我们所知，这是首例关于萘呋胺酯致命中毒的报道病例。
