Sagara N, Kawaji T, Koshiyama Y, Inomata Y, Fukushima M, Tanihara H
Department of Ophthalmology and Visual Science, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan.
Br J Ophthalmol. 2009 Oct;93(10):1337-40. doi: 10.1136/bjo.2008.149195. Epub 2009 Jun 10.
To investigate the frequency and risk factors of macular hole (MH) formation after rupture of a retinal arterial macroaneurysm.
Fifty-six eyes from 56 patients with rupture of a retinal arterial macroaneurysm with or without an MH (MH and non-MH groups, respectively) were reviewed. Frequency and risk factors related to MH formation were assessed, with risk factors including age; sex; distance from the macroaneurysm to the fovea; incidence of haemorrhages involving the macula such as preretinal, subinternal limiting membrane (sub-ILM), subretinal and vitreous; and vitreous surgery. MH formation in these patients was recorded and analysed.
Of the 56 eyes reviewed, seven (12.5%) had an MH after rupture of the retinal arterial macroaneurysm. The incidence of subretinal and sub-ILM haemorrhages involving the macula was significantly greater in the MH group than in the non-MH group (p = 0.037 and 0.045, respectively).
These results suggest that the presence of subretinal and sub-ILM haemorrhages after rupture of a retinal arterial macroaneurysm may contribute to formation of an MH.
研究视网膜动脉大动脉瘤破裂后黄斑裂孔（MH）形成的频率及危险因素。
回顾性分析56例视网膜动脉大动脉瘤破裂患者的56只眼，其中有或无MH（分别为MH组和非MH组）。评估与MH形成相关的频率及危险因素，危险因素包括年龄、性别、大动脉瘤至黄斑中心凹的距离、累及黄斑的出血发生率（如视网膜前、内界膜下、视网膜下及玻璃体积血）以及玻璃体手术。记录并分析这些患者中MH的形成情况。
在回顾的56只眼中，7只（12.5%）在视网膜动脉大动脉瘤破裂后出现了MH。MH组中累及黄斑的视网膜下及内界膜下出血发生率显著高于非MH组（分别为p = 0.037和0.045）。
这些结果表明，视网膜动脉大动脉瘤破裂后视网膜下及内界膜下出血的存在可能促使MH的形成。
