评价 MACS 队列中白人、西班牙裔和黑人男性对联合抗逆转录病毒治疗的依从性及其影响因素。
Evaluation of adherence and factors affecting adherence to combination antiretroviral therapy among White, Hispanic, and Black men in the MACS Cohort.
机构信息
Department of Epidemiology, School of Public Health, University of California, Los Angeles, CA 90095-1772, USA.
出版信息
J Acquir Immune Defic Syndr. 2009 Oct 1;52(2):290-3. doi: 10.1097/QAI.0b013e3181ab6d48.
OBJECTIVES
This study investigated levels of adherence to antiretroviral therapy in white, Hispanic, and black men and isolated factors associated with adherence among each racial group.
METHODS
Data were collected from 1102 men enrolled in the Multicenter AIDS Cohort Study followed between April 2002 and October 2006. Self-reported 100% adherence was defined as taking all doses and pills over the previous 4-day period, reporting not typically skipping any medications, and reporting always following the medication schedule. Variables associated with adherence were determined by multilevel logistic regression for each racial group. Adherence was also analyzed by ethnicity within racial groups.
RESULTS
After controlling for confounders, we found that Hispanics were 2.16 times and blacks were 1.37 times more likely than whites to not report 100% adherence (95% confidence interval 1.47 to 3.18 and 1.05 to 1.79, respectively). Hispanics with ethnic backgrounds from Central and South America and the Caribbean had lower rates of adherence. Blacks with ethnic backgrounds from the Caribbean had lower rates of adherence than those from other regions.
目的
本研究旨在调查白人、西班牙裔和黑人男性接受抗逆转录病毒治疗的依从水平，并分别分析每个种族群体中与依从性相关的因素。
方法
数据来自于参加多中心艾滋病队列研究的 1102 名男性，研究时间为 2002 年 4 月至 2006 年 10 月。自我报告的 100%依从性定义为在过去 4 天内服用了所有剂量和药丸，报告通常不会漏服任何药物，并且始终按照药物时间表服用。通过多水平逻辑回归确定每个种族群体中与依从性相关的变量。还按种族群体内的种族分析了依从性。
结果
在控制了混杂因素后，我们发现与白人相比，西班牙裔人群报告 100%依从性的可能性低 2.16 倍（95%置信区间为 1.47 至 3.18），黑人报告 100%依从性的可能性低 1.37 倍（95%置信区间为 1.05 至 1.79）。来自中美洲和南美洲以及加勒比地区的西班牙裔人群的依从率较低。来自加勒比地区的黑人的依从率低于来自其他地区的黑人。
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