Stem Cell Research Center, National Yang-Ming University, Taiwan.
Cell Transplant. 2009;18(9):1013-28. doi: 10.3727/096368909X471206. Epub 2009 Apr 29.
Mesenchymal stem cells are stem/progenitor cells originated from the mesoderm and can different into multiple cell types of the musculoskeletal system. The vast differentiation potential and the relative ease for culture expansion have established mesenchymal stem cells as the building blocks in cell therapy and tissue engineering applications for a variety of musculoskeletal diseases, including repair of fractures and bone defects, cartilage regeneration, treatment of osteonecrosis of the femoral head, and correction of genetic diseases such as osteogenesis imperfect. However, research in the past decade has revealed differentiation potentials of mesenchymal stem cells beyond lineages of the mesoderm, suggesting broader applications than originally perceived. In this article, we review the recent developments in mesenchymal stem cell research with respect to their emerging properties and applications in nonmusculoskeletal diseases.
间充质干细胞是一种起源于中胚层的干细胞/祖细胞，能够分化为多种骨骼肌肉系统的细胞类型。其巨大的分化潜能和相对容易的体外培养扩增，使其成为细胞治疗和组织工程应用的基石，可用于多种骨骼肌肉疾病的治疗，包括骨折和骨缺损的修复、软骨再生、股骨头坏死的治疗以及成骨不全等遗传性疾病的矫正。然而，过去十年的研究揭示了间充质干细胞的分化潜能超出了中胚层谱系，这表明其应用比最初预期的更为广泛。在本文中，我们综述了间充质干细胞研究的最新进展，及其在非骨骼肌肉疾病中的新特性和应用。
