Feldman E L, Bromberg M B, Albers J W, Pestronk A
Department of Neurology, University of Michigan, Ann Arbor.
Ann Neurol. 1991 Sep;30(3):397-401. doi: 10.1002/ana.410300312.
We report the results of immunosuppressive treatments of 13 patients with multifocal motor neuropathy and elevated titers of serum antibodies to the GM1 ganglioside. All patients failed to respond to oral prednisone. There was no clinical response in 4 patients treated with plasma exchange. Nine patients received cyclophosphamide, with clinical improvement and fall in antibody titers in 8. In 3 patients, cyclophosphamide was discontinued with ensuing clinical relapse and rise in the titers of serum anti-GM1 antibodies. These patients provide further evidence for the efficacy of cyclophosphamide therapy in patients with multifocal motor neuropathy.
我们报告了13例多灶性运动神经病且血清GM1神经节苷脂抗体滴度升高患者的免疫抑制治疗结果。所有患者对口服泼尼松均无反应。4例接受血浆置换治疗的患者无临床反应。9例患者接受了环磷酰胺治疗，其中8例临床症状改善且抗体滴度下降。3例患者停用环磷酰胺后临床复发，血清抗GM1抗体滴度升高。这些患者为环磷酰胺治疗多灶性运动神经病的疗效提供了进一步证据。
