Leffell D J, Headington J T, Wong D S, Swanson N A
Department of Dermatology, Yale University School of Medicine, New Haven, Conn. 06510.
Arch Dermatol. 1991 Nov;127(11):1663-7.
Aggressive-growth basal cell carcinoma (AG-BCC) defines a group of basal cell cancers that are histologically and clinically aggressive. This group includes morpheaform, infiltrating, and recurrent BCCs. Because of the clinical observation that the incidence of AG-BCC may be increased in patients under 35 years of age, compared with those older, we performed a retrospective study. We reviewed the pathologic findings of 3381 patients diagnosed with BCC, including 102 patients with BCC referred for Mohs surgery to determine whether AG-BCC occurs with increased frequency in patients younger than than 35 years of age. Among patients under 35 years of age, 38% of women had AG-BCC compared with 9% of women in the older age group. Similarly, 25% of men under 35 years of age had AG-BCC compared with 11% among men in the older age group. Aggressive-growth BCC is more frequently noted in patients under 35 years of age than in those older. Failure to diagnose this type of BCC, which may be clinically subtle, may lead to incomplete or inadequate treatment. Because of the tendency of these tumors to recur, greater long-term morbidity may result.
侵袭性生长基底细胞癌（AG-BCC）是一组在组织学和临床上具有侵袭性的基底细胞癌。这一组包括硬斑病样、浸润性和复发性基底细胞癌。由于临床观察发现，与年龄较大的患者相比，35岁以下患者中AG-BCC的发病率可能会增加，因此我们进行了一项回顾性研究。我们回顾了3381例被诊断为基底细胞癌患者的病理结果，其中包括102例因莫氏手术转诊的基底细胞癌患者，以确定AG-BCC在35岁以下患者中是否更频繁地发生。在35岁以下的患者中，38%的女性患有AG-BCC，而在年龄较大的女性组中这一比例为9%。同样，35岁以下的男性中有25%患有AG-BCC，而年龄较大的男性组中这一比例为11%。侵袭性生长基底细胞癌在35岁以下患者中比在年龄较大的患者中更常见。未能诊断出这种在临床上可能不明显的基底细胞癌类型，可能会导致治疗不完整或不充分。由于这些肿瘤有复发的倾向，可能会导致更高的长期发病率。
