[利福平与微生物肽聚糖在实验性鼠疫感染中的联合作用多因素研究]

[Multifactorial study of the combined effect of rifampicin and microbial peptidoglycan in experimental plague infection].

作者信息

Nikitin A V, Makarovskaia L N, Fomina I P, Ivanitskaia L P, Popova G O, Vinidchenko N N, Korganov Ia N, Bodunkova L E

出版信息

Antibiot Khimioter. 1991 May;36(5):23-5.

Abstract

The combined effect of rifampicin and a microbial peptidoglycan was studied in multifactorial experiments on noninbred mice with plague infection. The effect of rifampicin and the immunomodulator was shown to be synergistic. The results of the multifactorial experiments provided designing of polynomial statistic models of the second order characterizing the animal survival rate and mean life-span and plotting of nomograms or equal level lines useful in optimization of the combined therapy parameters.

摘要

在对感染鼠疫的非近交系小鼠进行的多因素实验中，研究了利福平与一种微生物肽聚糖的联合作用。结果表明，利福平和免疫调节剂的作用具有协同性。多因素实验结果为设计表征动物存活率和平均寿命的二阶多项式统计模型以及绘制列线图或等水平线提供了依据，这些对于优化联合治疗参数很有用。

相似文献

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[Multifactorial study of the combined effect of rifampicin and microbial peptidoglycan in experimental plague infection].[利福平与微生物肽聚糖在实验性鼠疫感染中的联合作用多因素研究]

Antibiot Khimioter. 1991 May;36(5):23-5.

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